Topic
Hydroxysteroid dehydrogenase
About: Hydroxysteroid dehydrogenase is a research topic. Over the lifetime, 1087 publications have been published within this topic receiving 28468 citations. The topic is also known as: hydroxysteroid dehydrogenase.
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2 citations
TL;DR: It is proposed that the geometry of the steroid binding site is such as to allow for compounds such as C18 and C19 17β-hydroxysteroids to bind but that a minimum size is required for tight binding, consistent with previous observations on human placental 17 β-Hydroxysteroid dehydrogenase and estrogen receptor.
2 citations
Patent•
13 Dec 2004TL;DR: In this paper, substituted thiophenepyrimidinone derivatives and their use in therapy, especially for use in the treatment and/or prevention of a steroid hormone dependent diseases or disorder, such as steroid hormone-dependent diseases or disorders requiring inhibition of 17β-hydroxysteroid dehydrogenase enzymes.
Abstract: This invention relates to novel substituted thiophenepyrimidinone derivatives and their use in therapy, especially for use in the treatment and/or prevention of a steroid hormone dependent diseases or disorder, such as steroid hormone dependent diseases or disorders requiring inhibition of 17β-hydroxysteroid dehydrogenase enzymes.
2 citations
Patent•
16 Dec 2011
TL;DR: In this article, the 7s-hydroxysteroid dehydrogenase mutants, the sequences which encode these enzyme mutants, and the processes for the preparation of the enzyme mutants and their use in enzymatic reactions of cholic acid compounds were described.
Abstract: The invention relates to novel 7s-hydroxysteroid dehydrogenase mutants, to the sequences which encode these enzyme mutants, to processes for the preparation of the enzyme mutants and to their use in enzymatic reactions of cholic acid compounds, in particular in the preparation of ursodeoxycholic acid (UDCS). The invention also relates to novel processes for the synthesis of UDCS using the enzyme mutants; and to the preparation of UDCS using recombinant, multiply-modified microorganisms.
2 citations