Hydroxysteroid dehydrogenase

About: Hydroxysteroid dehydrogenase is a research topic. Over the lifetime, 1087 publications have been published within this topic receiving 28468 citations. The topic is also known as: hydroxysteroid dehydrogenase.

Process for the preparation of 4-(8-(2-chlorophenoxy)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)bicyclo[2.2.1]heptan-1-ol and novel intermediates therefor

Abstract: A process is provided for preparing 4-(8-(2-chlorophenoxy)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)bicyclo[2.2.1]heptan-1-ol and novel intermediates used in the process. The compound is a 11-beta hydroxysteroid dehydrogenase type I inhibitor which exhibits activity in the treatment of various metabolic diseases.

SELECTIVE INHIBITORS OF 11ß-HYDROXYSTEROID DEHYDROGENASE TYPE 1

Abstract: The invention relates to an inhibitor of 11s hydroxysteroid dehydrogenase (11s-HSD), which exclusively inhibits 11s hydroxysteroid dehydrogenase type 1, but not 11s hydroxysteroid dehydrogenase type 2.

17β-hydroxysteroid dehydrogenase-3 deficiency in disorder of sex development.

Abstract: Mymensingh Med J. 2012 Jan;21(1):170-174 The abstract of this article is available on the PubMed website

3B-Hydroxysteroid Dehydrogenase Activity in the Adrenal Gland of the Chick Embryo

Abstract: The adrenal glands of white and brown Leghorn embrtJOS and chicks were examined for histochemically demonstrable 3S-hydro:xysteroid:NAD oxidoreductase i (3S-hydro.xy-steroid dehydrogenase or 3S-HSD) using pregnenolone (P) and dehydro-1 epiandrosterone (DHA.) as substrates. Traces of Pand DHA.-JS-HSD activity were I seen as early as stage 22 (3.5 4 days) in adrenocortical cells of nomal I embryos. These activities gradually increased through eight days of incuba.tion1 and were eve~ distributed thr~ughout the adrenocortical tissue; however, PJS-HSD was always greater than DHA-~-HSD activity. Beginning at stage 30 (6.5 7 days) the first indications of a zonation were observed in the adrenals of some embryos. From nine days through hatching and during the first two weeks after hatching, the adrenal glands showed a narrow peripheral cortical zone of high P-JS-F.SD and low DHA-3S-HSD and a large central zone of low . P-)S-HSD and high DHA-3S-HSD activity. These observations suggest the presence of two substrate-specific 3S-l'zydro:xysteroid dehydrogenases. No differences were observed in the distribution or degree of activity of DHAand P3S-HSD between white and brown Leghorn embryos or chicks. Hypopl'zysectomy by the partial decapitation method of Fugo ( 140) at stages 10 or 11 (.'.33 to 45 hours), had no effect on the morphological development of the adrenal glands from stage 22 through nine days of incubation. Beginning at about ten days and continuing through the remainder of the incubation period, the cortical cords of hypophysectomized embryos were hypertrophied and reduced in number and the size of the groups of chranaffin (medullary) cells were larger than normal. Hypophysectomy had no effect on DHAor P-~-HSD activity from stage 22 through eight days of incubation. xvi after this period many of the adrenal glands of hypophysectomized embryos lacked cortical zones and when these did occur the peripheral was wider and the central zone smaller than those of no:nnal or sham operated embryos. From eight through 19 days, the central zone P-3f3-HSD activity of hypophysectomized embryos was higher than that of sham operated embryos and from 12 through 19 days. the peripheral zone activity was lower than that of controls. Central zone DF.A-3f3-HSD activity of hypophysectomized embryos was equal to that of sham operated controls from eight through 12 days but after this period the central zone activity was lower than in controls. The peripheral zone DHA3f3-HSD activity of hypophysectomized embryos was equal to that of controls from eight through 19 days. When hypophysectomized 8.5 day old embryos received single, whole adenoI hypophyses from 17 day donor embryos, transplanted on the chorio~toic membrane, all of the adrenal glands showed zonations from nine through 19 days and the size of the zones appeared to be about nomal. The Pand DHA-Jf3-HSD activity levels in both the peripheral and central zone were at levels characI teristic of embryos with intact pituitary glands. The distribution and levels of 313-HSD activity in the adrenal glands of hypophysectomized embryos, which had received daily administration of ACTH on the chorioallantoic membrane beginning at eight days, were also characteristic of intact embryos. The results of this investigation indicate that the adrenocortical cells of the chick have a steroidogenic potential as soon as they become recogniz,, able early in developnent. Cortical zones ~gin to appear on the eighth dayof' I incubation· and. are see.n in all adrenal glands by nine days. Following hypophy-1 sectomy there appeared to be either a retardation or a failure in the development of the central cortical zone. Adenohypophyseal transplants, as well as the administration o.r ACTH, prevent the effects of hypophysectany.