Hydroxysteroid dehydrogenase

About: Hydroxysteroid dehydrogenase is a research topic. Over the lifetime, 1087 publications have been published within this topic receiving 28468 citations. The topic is also known as: hydroxysteroid dehydrogenase.

Evaluation of Anti-Steroidogenic Activity of Petroleum Ether Extract of Celsia coromandeliane Vahl in Mouse Ovary

Abstract: The petroleum ether extract of Celsia coromandeliane Vahl (PECC) arrested the normal estrus cycle of adult female mouse and significantly decreased the weight of ovaries and uterus. The cholesterol and ascorbic acid contents in ovaries were significantly increased in treated mice. Two key enzymes,  5 -3– hydroxysteroid dehydrogenase (  5 -3-HSD) and glucose-6-phosphate dehydrogenase (G-6-PDH), were decreased significantly in PECC treated mice after 17 days of treatment. High level of substrates and low level of enzymes indicate the inhibition of steroidogenesis in treated mice and may be due to the presence of sterols. Keywods : Celsia coromandeliane ,  5 -3–hydroxysteroid dehydrogenase(HSD), glucose-6-phosphate dehydrogenase, mouse ovary.

Notice of Retraction A Cluster of Five Hydroxysteroid Dehydrogenase Genes Belonging to the Aldo-Keto Reductase Supergene Family on Human Chromosome 10

Abstract: Over recent years, much attentions have focused on the hydroxysteroid dehydrogenases (HSD) subfamily members belonging to the aldo-keto reductase (AKR) 1C subfamily (AKR1C). This is due to the ability of AKR1C enzymes to modify androgens, estrogens, progesterone and prostaglandins (PGs) in a tissue-specific manner, regulating the activity of nuclear receptors and other downstream effects. In the study, we describe a cluster of the HSDs gene family on human chromosome 10. These include four previously reported human HSD genes (AKR1-C1, -C2, -C3, and AKR1-C4) and a more distantly related AKR1E2. We also compared the five human and the ninty murine isoforms in their phylogeny. Our results demonstrate that at least AKR1E2 should reside in the AKR gene cluster and was clearly the most divergent of the four AKR1C proteins.

Gene S1-a-1 of novel 7 alpha-HSDH (hydroxysteroid dehydrogenase)

Abstract: The invention relates to HSDH (hydroxysteroid dehydrogenase), in particular to a gene S1-a-1 of novel 7 alpha-HSDH. A nucleotide sequence of the gene is shown as SEQ ID NO.2, the novel 7 alpha-HSDH is encoded, a nucleotide sequence of the novel 7 alpha-HSDH is shown as SEQ ID NO.1, the novel 7 alpha-HSDH can be used for catalyzing CDCA (chenodeoxycholic acid) and TCDCA (taurochenodeoxycholic acid) to generate 7K-LCA (7-ketone lithocholic acid) and T7K-LCA (taurine-7-ketone lithocholic acid), wherein the catalytic activity of the novel 7 alpha-HSDH for CDCA is about 5 times of that of 7 alpha-HSDH of Sardinia clostridium, and the catalytic activity of the novel 7 alpha-HSDH for TCDCA is about over 2.5 times of that of 7 alpha-HSDH of Sardinia clostridium, therefore, the novel 7 alpha-HSDH has a great industrial application value.