Topic
Hydroxysteroid dehydrogenase
About: Hydroxysteroid dehydrogenase is a research topic. Over the lifetime, 1087 publications have been published within this topic receiving 28468 citations. The topic is also known as: hydroxysteroid dehydrogenase.
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TL;DR: While some studies demonstrate impaired 11 beta-HSD activity in broader populations of patients with hypertension, further studies are required to clarify the role of 11beta- HSD2 in 'essential' hypertension.
41 citations
TL;DR: The effects of FSH, hCG, and PRL on the activity of 20 alpha-hydroxysteroid dehydrogenase of separate ovarian components of hypophysectomized, diethylstilbestrol-treated rats were studied and enzyme activity was found to reside mainly in granulosa cells.
Abstract: The effects of FSH, hCG, and PRL on the activity of 20α-hydroxysteroid dehydrogenase (20α-SDH) of separate ovarian components of hypophysectomized, diethylstilbestroltreated rats were studied. Enzyme activity was found to reside mainly in granulosa cells. FSH induced an increase in enzyme activity. A preparation of FSH was purified by adsorbing its LH contamination on rat corpora lutea membranes and by further neutralizing LH traces with an antiserum to the β-subunit of LH. This purified FSH retained the ability to induce a 6-fold increase in specific enzyme activity in granulosa cells of hypophysectomized, diethylstilbestrol-treated rats. Administration of hCG to rats treated with purified FSH, further enhanced 20α- SDH activity in granulosa cells up to 11.5-fold above control. PRL, which is known to inhibit 20α-SDH activity in regressing rat corpora lutea, suppressed the FSH-induced increase in enzyme activity in the granulosa cells.
41 citations
TL;DR: It is proposed that progesterone produced during the first half of mouse pregnancy in decidua and giant trophoblast cells acts as an immunosuppressant at the fetal maternal interface to prevent rejection of the fetus.
41 citations
TL;DR: To investigate the specific roles of H SD2 in vivo, "floxed" HSD2 alleles are created using gene targeting in mouse embryonic stem cells with the aim to create tissue-specific ablation of HSD1 in mice via Cre recombinase mediated gene targeting.
40 citations
TL;DR: The absence of activity from preparations of rat ovary 2Oar-hydroxysteroid dehydrogenase is reported and it is demonstrated that this lack of transhydrogenase activity stems from the single pyridine nucleotide requirement of the enzyme.
40 citations