Topic
Hydroxysteroid dehydrogenase
About: Hydroxysteroid dehydrogenase is a research topic. Over the lifetime, 1087 publications have been published within this topic receiving 28468 citations. The topic is also known as: hydroxysteroid dehydrogenase.
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TL;DR: Structural-function studies of aromatase, estrone sulfatase and 17β-hydroxysteroid dehydrogenase type 1 are important to evaluate the molecular basis of the interaction between these enzymes and their inhibitors.
32 citations
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TL;DR: This work selected several positions for the replacement of amino acids by site-directed mutagenesis to change substrate specificity, alter coenzyme requirements, and improve overall catalytic activity of the 17beta-HSD.
32 citations
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21 May 2004
TL;DR: In this article, a method for promoting wound healing was proposed, which consisted of administering to a mammal, including man, in need of such promotion an effective amount of an inhibitor of 11-s-hydroxysteroid dehydrogenase type 1.
Abstract: The invention relates to a method for promoting wound healing, said method comprising administering to a mammal, including man, in need of such promotion an effective amount of an inhibitor of 11-s-hydroxysteroid dehydrogenase type 1 wherein the said l ls-HSD1 inhibitor has the formula (I) wherein T, R1, A1 and A2 are as defined in the specification. These compounds may also be used in the manufacture of a medicament for promoting wound healing.
32 citations
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TL;DR: Rat Ovarian 20α-hydroxysteroid dehydrogenase has been purified 25 fold by fractional ammonium sulfate precipitation and DEAE-cellulose chromatography and it was concluded that a planar α-face of the steroid ring is not necessary for reactivity.
32 citations
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TL;DR: A human fecal isolate, characterized by morphological, physiological and biochemical data as a strain of Peptostreptococcus roductus, was shown to contain NAD-dependent 3α- and 3β-hydroxysteroid dehydrogenases and a NADP-dependent 7β-Hydroxysteroids dehydrogenase, which could be demonstrated in crude extracts and in membrane fractions.
32 citations