Topic
Hydroxysteroid dehydrogenase
About: Hydroxysteroid dehydrogenase is a research topic. Over the lifetime, 1087 publications have been published within this topic receiving 28468 citations. The topic is also known as: hydroxysteroid dehydrogenase.
Papers published on a yearly basis
Papers
More filters
TL;DR: The results suggest that false negative receptor assays in the premenopausal women is not likely to be due to occupancy of receptors by endogenous estrogens, and the higher estrone content in the ER negative group is probably due to high 17 beta-hydroxysteroid dehydrogenase activity inherent to these tumor cells.
31 citations
TL;DR: The results suggest that pregnenolone might be synthesized from cholesterol by P450scc de novo and then, it is converted to progesterone by 3β-HSD in the uterine endometrium.
Abstract: The enzyme complex 3b-hydroxysteroid dehydrogenase/Δ(5)-Δ(4)-isomerase (3β-HSD) is involved in the biosynthesis of all classes of active steroids The expression of 3β-HSD in human uterine endometrium during the menstrual cycle and decidua was examined in an effort to understand its role during ova implantation 3β-HSD was weakly expressed in the glandular epithelium of the proliferative phase and moderately expressed in the glandular epithelium of secretory phase of the endometrium In the decidua of the ectopic pregnancy, 3β-HSD was strongly expressed The human uterine endometrial 3β-HSD was identified as being the same type as the placental 3β-HSD by RT-PCR and sequence analysis In addition to the expression of 3β-HSD, P450scc was expressed in the decidua of the ectopic pregnancy These results suggest that pregnenolone might be synthesized from cholesterol by P450scc de novo and then, it is converted to progesterone by 3β-HSD in the uterine endometrium The data implies that the endometrial 3β-HSD can use not only the out-coming pregnenolone from the adrenal gland but also the self- made pregnenolone to produce progesterone The de novo synthesis of progesterone in the endometrium might be a crucial factor for implantation and maintenance of pregnancy
31 citations
Journal Article•
31 citations
TL;DR: This study provides the first evidence that a novel 17β-HSD in Rhodococcus sp.
31 citations
TL;DR: Using a structure- and ligand-based approach, a pharmacophore model was proposed and a new class of non-steroidal inhibitors of 17beta-HSD1 was designed, and the potency of this class of inhibitors was improved by substitution of the 1-position of the naphthalene ring by a phenyl group.
31 citations