Topic
Hydroxysteroid dehydrogenase
About: Hydroxysteroid dehydrogenase is a research topic. Over the lifetime, 1087 publications have been published within this topic receiving 28468 citations. The topic is also known as: hydroxysteroid dehydrogenase.
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TL;DR: Blood cells of male and female rainbow trout showed 17(3-hydroxysteroid dehydrogenase (17(βHSD) activity in vitro, reducing 11β-hydroandrostenedione and 11-ketoandro-stenedione (OA) to 11 β-Hydroxytestosterone and11-ketotestosterone (OT), respectively, respectively, which appears to be present in a variety of trout issues.
27 citations
Journal Article•
27 citations
TL;DR: A series of 4,5-disubstituted cis-pyrrolidinones was investigated as inhibitors of 17beta-HSD II for the treatment of osteoporosis and compound 42 was selected as the lead candidate.
27 citations
TL;DR: Although 21-hydroxypregnenolone has not been found to be one of the dominant reducing steroids in the urine of newborn infants, it has been shown to be consistently present and to be easily measurable during the first week of life (Cathro et al., 1963).
Abstract: The unusual patterns of excretion of steroids of adrenal or placental origin occurring in the urine of normal newborn infants have been the subject of previous reports (Birchall, Cathro, Forsyth, and Mitchell, 1961; Cathro, Birchall, Mitchell, and Forsyth, 1963) and have been interpreted as providing evidence that the metabolism of adrenal steroids in early infancy is unique. The presence of atypical urinary neutral steroids is characteristic of the first week of life and one of these has been provisionally identified as the J15-compound 3r: 21-dihydroxypregn-5-ene-20-one (Cathro et al., 1963). Further study of the isolated material (Birchall and Mitchell, to be published) has supported the original provisional identification of the compound as 33: 21-dihydroxypregn-5-ene-20-one (21-hydroxypregnenolone), and the occurrence of this steroid in the urine ofnewborn infants is ofconsiderable theoretical importance, since it suggests that in early infancy adrenal steroids may be synthesized by pathways that are unimportant in the adult. Although 21-hydroxypregnenolone has not been found to be one of the dominant reducing steroids in the urine of newborn infants, it has been shown to be consistently present and to be easily measurable during the first week of life (Cathro et al., 1963). This is in marked contrast to what is found with adult males, in whom urinary excretion of 21hydroxypregnenolone as the 3: 21-disulphate occurs in such small quantities that the average value obtained following corticotrophin stimulation is only 70 ,Lg./litre (Pasqualini, 1962; Pasqualini and Jayle, 1962). This low excretion of the steroid by adults is
27 citations
27 citations