Topic
Hydroxysteroid dehydrogenase
About: Hydroxysteroid dehydrogenase is a research topic. Over the lifetime, 1087 publications have been published within this topic receiving 28468 citations. The topic is also known as: hydroxysteroid dehydrogenase.
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TL;DR: A method to estimate semiquantitatively the activity of HSD enzymes and is described in detail, which depends on demonstrating NAD‐dependent hydroxysteroid dehydrogenase by using nitro‐BT as a hydrogen acceptor leading to the deposition of blue diformazan particles.
Abstract: SUMMARY. A method has been established to estimate semiquantitatively the activity of HSD enzymes and is described in detail. In the main, the method depends on demonstrating NAD-dependent hydroxysteroid dehydrogenase by using nitro-BT as a hydrogen acceptor leading to the deposition of blue diformazan particles. The latter are then counted in a sebaceous gland by means of a Wild M20 microscope with a drawing tube attachment. The method is limited in use as a semi-quantitative comparison of enzyme activity in a few adjacent sections of a sebaceous gland.
22 citations
TL;DR: Analysis of the impact of 17β-HSD10 and its inhibitor, amyloid-β peptide (Aβ), on the metabolism of neuroactive steroids offers a new approach to AD pathogenesis.
Abstract: 17β-Hydroxysteroid dehydrogenase type 10 is a multifunctional, homotetrameric, mitochondrial protein encoded by the HSD17B10 gene at Xp 11.2. This protein, 17β-HSD10, is overexpressed in brain cells of Alzheimer's disease (AD) patients. It was reported to be involved in AD pathogenesis as the endoplasmic reticulum-associated amyloid-β binding protein (ERAB) and as amyloid-β binding alcohol dehydrogenase (ABAD). However, the exaggerated catalytic efficiencies for ERAB/ABAD in these reports necessitated the re-characterization of the catalytic functions of this brain enzyme. In addition to isoleucine metabolism, 17β-HSD10 is also responsible for the mitochondrial metabolism of neurosteroids such as 5α-androstane-3α,17β-diol and 17β-estradiol. These neurosteroids are inactivated by the oxidation catalyzed by 17β-HSD10. Since neurosteroid homeostasis is presumably essential for cognitive function, analysis of the impact of 17β-HSD10 and its inhibitor, amyloid-β peptide (Aβ), on the metabolism of neuroactive steroids offers a new approach to AD pathogenesis.
22 citations
TL;DR: It is suggested that bFGF may have a regulatory role in placental estrogen metabolism via its effects on 17-HSD type 1 through its regulation by basic fibroblast growth factor in choriocarcinoma cell lines.
22 citations
TL;DR: The findings suggest that Cf-17β-HSD8 may play an important role in regulating gametogenesis through modulating E2 levels in gonad of C. farreri.
22 citations
TL;DR: DHRS11 represents a novel type of 17β-hydroxysteroid dehydrogenase with unique catalytic properties and tissue distribution and was observed widely in human tissues, most abundantly in testis, small intestine, colon, kidney and cancer cell lines.
22 citations