scispace - formally typeset
Search or ask a question
Topic

Hydroxysteroid dehydrogenase

About: Hydroxysteroid dehydrogenase is a research topic. Over the lifetime, 1087 publications have been published within this topic receiving 28468 citations. The topic is also known as: hydroxysteroid dehydrogenase.


Papers
More filters
Journal ArticleDOI
TL;DR: In this paper, a series of adamantyl carboxamides were used as selective inhibitors of human 11β-hydroxysteroid dehydrogenases (11β-HSDs) in HEK-293 cells transfected with the HSD11B1 gene.

19 citations

Journal ArticleDOI
01 Jul 1980-Steroids
TL;DR: It is suggested that estradiol-17β caused an increase in enzyme activity that was inhibitable by progesterone in the rat uterus, and the increased 17β -hydroxysteroid dehydrogenase activity may reflect a specific response of theRat uterus to estradio-17 β.

19 citations

Journal ArticleDOI
11 Oct 1963-Science
TL;DR: The time course of the appearance and disappearance of the enzyme, the absence of detectable inhibitors and activators, and evaluation of cofactor requirements suggest that this may be an example of enzyme induction by the hormone.
Abstract: The activity of an enzyme system which readily converts estriol to 16-ketoestradiol is present only in the kidneys of mature female rats and is absent in the kidneys of male rats and immature rats of either sex. The full enzyme activity occurs in kidneys of rats of either sex at any stage of maturity after administration of estradiol for 2 weeks. The time course of the appearance and disappearance of the enzyme, the absence of detectable inhibitors and activators, and evaluation of cofactor requirements suggest that this may be an example of enzyme induction by the hormone. Furthermore, the enzyme activity itself represents a metabolic pathway for estriol metabolism whose potential quantitative significance has not heretofore been recognized.

19 citations

Journal ArticleDOI
TL;DR: 5-(3-Bromo-4-hydroxybenzylidene)-3-(4-methoxyphenyl)-2-thioxo-1,3-thiazolidin- 4-one exhibited a promising activity profile and demonstrated significant selectivity over the related 17β-HSD isoenzymes and nuclear receptors.

19 citations

Journal ArticleDOI
TL;DR: The isolation of a mouse 3alpha-HSD cDNA and the characterization of its substrate specificity and tissue distribution suggest that m3alpha- HSD could play an important role in the female mouse physiology similar to that of type 1 5alpha-reductase with which it works in tandem.

19 citations


Network Information
Related Topics (5)
Hormone
38.3K papers, 1.2M citations
83% related
Estrogen
40.7K papers, 1.7M citations
83% related
Estrogen receptor
34.2K papers, 1.4M citations
80% related
Secretion
24.8K papers, 1.2M citations
78% related
Receptor
159.3K papers, 8.2M citations
78% related
Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202319
202217
20218
202016
201916
20186