Topic
Hydroxysteroid dehydrogenase
About: Hydroxysteroid dehydrogenase is a research topic. Over the lifetime, 1087 publications have been published within this topic receiving 28468 citations. The topic is also known as: hydroxysteroid dehydrogenase.
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TL;DR: In this paper, a series of adamantyl carboxamides were used as selective inhibitors of human 11β-hydroxysteroid dehydrogenases (11β-HSDs) in HEK-293 cells transfected with the HSD11B1 gene.
19 citations
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TL;DR: It is suggested that estradiol-17β caused an increase in enzyme activity that was inhibitable by progesterone in the rat uterus, and the increased 17β -hydroxysteroid dehydrogenase activity may reflect a specific response of theRat uterus to estradio-17 β.
19 citations
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TL;DR: The time course of the appearance and disappearance of the enzyme, the absence of detectable inhibitors and activators, and evaluation of cofactor requirements suggest that this may be an example of enzyme induction by the hormone.
Abstract: The activity of an enzyme system which readily converts estriol to 16-ketoestradiol is present only in the kidneys of mature female rats and is absent in the kidneys of male rats and immature rats of either sex. The full enzyme activity occurs in kidneys of rats of either sex at any stage of maturity after administration of estradiol for 2 weeks. The time course of the appearance and disappearance of the enzyme, the absence of detectable inhibitors and activators, and evaluation of cofactor requirements suggest that this may be an example of enzyme induction by the hormone. Furthermore, the enzyme activity itself represents a metabolic pathway for estriol metabolism whose potential quantitative significance has not heretofore been recognized.
19 citations
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TL;DR: 5-(3-Bromo-4-hydroxybenzylidene)-3-(4-methoxyphenyl)-2-thioxo-1,3-thiazolidin- 4-one exhibited a promising activity profile and demonstrated significant selectivity over the related 17β-HSD isoenzymes and nuclear receptors.
19 citations
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TL;DR: The isolation of a mouse 3alpha-HSD cDNA and the characterization of its substrate specificity and tissue distribution suggest that m3alpha- HSD could play an important role in the female mouse physiology similar to that of type 1 5alpha-reductase with which it works in tandem.
19 citations