Topic
Hypoventilation
About: Hypoventilation is a research topic. Over the lifetime, 1772 publications have been published within this topic receiving 40799 citations. The topic is also known as: respiratory depression.
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TL;DR: In anesthetised cats, breathing pattern, blood gases, and ventilatory response to CO2 were recorded before and during intermittent 10-minute episodes of hydrostatically raised intracranial pressure, finding no evidence of a neurally mediated effect on the lungs, causing defective gas exchange.
Abstract: ✓ In anesthetised cats, breathing pattern, blood gases, and ventilatory response to CO2 were recorded before and during intermittent 10-minute episodes of hydrostatically raised intracranial pressure. The first effect on breathing was a stimulation which was followed at higher pressures by irregularity, depression, and periods of apnea; hyperventilation at high intracranial pressure (ICP) was rare. Raised ICP did not consistently depress the ventilatory response to CO2 until ventilation during airbreathing was already depressed; therefore, we cannot experimentally justify applying this test clinically to detect incipient ventilatory depression. When hypoxemia developed during raised ICP, it was compatible with the degree of hypoventilation due to central depression of breathing; thus, there was no evidence of a neurally mediated effect on the lungs, causing defective gas exchange.
10 citations
TL;DR: In the presented case, basal levels of PCO2 increased from hypocapnic to normocapnic range over the course of treatment, accompanied by improvements in lung function and reductions in diurnal lung function variability.
Abstract: Hyperventilation-induced hypocapnia is common among asthma patients. This case study illustrates both methodology and results from a patient undergoing training in capnometry-assisted respiratory training (CART). CART is a 4-week training aimed at normalizing basal and acute levels of end-tidal carbon dioxide (PCO2) using a portable capnometer. In the presented case, basal levels of PCO2 increased from hypocapnic to normocapnic range over the course of treatment. Improvements were accompanied by improvements in lung function and reductions in diurnal lung function variability. Improvements remained stable throughout follow-up.
10 citations
Journal Article•
TL;DR: In the monitoring of this mechanical ventilation new tools are needed, initiating nocturnal ventilation with systematic respiratory polygraphic studies seems to be justified, and indication on mechanical ventilation in ALS is discussed.
10 citations
TL;DR: Tracheal pressures during airway occlusion, inspiratory time, alveolar ventilation, and Paco2 were measured in spontaneously breathing, healthy patients during enflurane: N2O anesthesia at various inspired concentrations of en flurane to describe more clearly the mechanism of intraoperative hypoventilation.
Abstract: Tracheal pressures during airway occlusion (an index of ventilatory drive), inspiratory time, alveolar ventilation, and PaCO2 were measured in spontaneously breathing, healthy patients during enflurane:N2O anesthesia at various inspired concentrations of enflurane. The purpose was to describe more clearly the mechanism of intraoperative hypoventilation. Occlusion pressures, inspiratory time, and alveolar ventilation were less, and PaCO2 was higher, at deeper levels of anesthesia. Hypoventilation is due to reduced mechanical transform of neuromuscular drive and to shorter inspiratory time and, therefore, reduced mean inspiratory flow rate without change in breathing frequency. Effective elastance (an index of lung stiffness) was slightly greater at deeper levels of anesthesia.
10 citations
TL;DR: The mechanisms of action and monitoring of neuromuscular blocking agents are reviewed, as well as a basic overview of postoperative complications involving hypoventilation and motor weakness are provided.
10 citations