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Hypoventilation

About: Hypoventilation is a research topic. Over the lifetime, 1772 publications have been published within this topic receiving 40799 citations. The topic is also known as: respiratory depression.


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Journal ArticleDOI
TL;DR: It is hypothesize that capnography could detect hypoventilation during induction of bronchoscopic sedation and starting bronchoscopy following hypventilation, may decrease hypoxemia without compromising patient tolerance.
Abstract: We hypothesize that capnography could detect hypoventilation during induction of bronchoscopic sedation and starting bronchoscopy following hypoventilation, may decrease hypoxemia. Patients were randomized to: starting bronchoscopy when hypoventilation (hypopnea, two successive breaths of at least 50% reduction of the peak wave compared to baseline or apnea, no wave for 10 seconds) (Study group, n = 55), or when the Observer Assessment of Alertness and Sedation scale (OAAS) was less than 4 (Control group, n = 59). Propofol infusion was titrated to maintain stable vital signs and sedative levels. The hypoventilation during induction in the control group and the sedative outcome were recorded. The patient characteristics and procedures performed were similar. Hypoventilation was observed in 74.6% of the patients before achieving OAAS < 4 in the control group. Apnea occurred more than hypopnea (p < 0.0001). Hypoventilation preceded OAAS < 4 by 96.5 ± 88.1 seconds. In the study group, the induction time was shorter (p = 0.03) and subjects with any two events of hypoxemia during sedation, maintenance or recovery were less than the control group (1.8 vs. 18.6%, p < 0.01). Patient tolerance, wakefulness during sedation, and cooperation were similar in both groups. Significant hypoventilation occurred during the induction and start bronchoscopy following hypoventilation may decrease hypoxemia without compromising patient tolerance.

5 citations

Journal ArticleDOI
TL;DR: The original narrative of central alveolar hypoventilation syndrome, its characters, and how it is linked to the most relevant aspects of the disease are reviewed.
Abstract: Central alveolar hypoventilation syndrome has been known for decades as Ondine's curse. It was named as such after a German myth. Although most of the stories resemble one another, word of mouth has led to misinterpretation of this tale among the medical community. The present paper reviews the original narrative, its characters, and how it is linked to the most relevant aspects of the disease.

5 citations

Journal ArticleDOI
TL;DR: J B, girl aged 13 months Born at 31 weeks gestation, birth weight 1-7 kg, had the first of a series of apnoeic spells which continued for the next 25 days which made an uneventful recovery.
Abstract: J B, girl aged 13 months Born at 31 weeks gestation, birth weight 1-7 kg. Her immediate postnatal course was uneventful apart from mild jaundice. At 51 days she had the first of a series of apnoeic spells which continued for the next 25 days. Between attacks her breathing was shallow. Repeated chest X-rays taken during course of illness were normal and all investigations carried out to elucidate the cause of the attacks were negative. The only abnormal findings were a low pH and a compensated respiratory acidosis (Fig 1). The initial Po2 was 52 mmHg. At 80 days these findings began to improve and thereafter she made an uneventful recovery.

5 citations

Journal ArticleDOI
TL;DR: Le traitement specifique par immunoglobuline antitoxine botulinique n'a pas ete entrepris en raison du delai de plus de 7 jours ecoule apres le debut des symptomes.
Abstract: Botulism was suspected in a 17-day-old breastfed infant who developed over 2 days progressive muscular weakness and hypoventilation. The patient also presented with pupil dilation and light unresponsiveness. The electroencephalogram was normal. Full recovery was obtained after 85 days of artificial ventilation. Diagnosis was confirmed by the presence of the botulin toxin B in the patient serum. The source of the infection was not identified.

5 citations

Journal ArticleDOI
TL;DR: A case study is used to explore the ethical issues of provision of treatment, or non‐treatment, of children with CCHS, a well‐recognized disorder of the autonomic nervous system caused by mutations in the PHOX2B gene.
Abstract: Congenital central hypoventilation syndrome (CCHS) is a well-recognized disorder of the autonomic nervous system caused by mutations in the PHOX2B gene. The most characteristic feature is failure of ventilatory control, resulting in the need for respiratory support while asleep, and in some cases when awake also. Most cases present in infancy or early childhood. Technological advances allow patients with mild to moderate phenotypesto receive adequate support by non-invasive ventilation (NIV), or diaphragm pacing (or combination of the two) avoiding the need for long-term ventilation by tracheostomy. Daytime functioning of patients with CCHS who require sleep-time ventilation only is expected to be good, with some additional surveillance to ensure they don't accidentally fall asleep without respiratory support available. Some children with CCHS have other complications, such as Hirschprung's disease, learning difficulties, and cardiac arrhythmias (leading in some instances to heart block and the requirement for a pacemaker). In a few cases, patients can develop neurogenic malignancies. Parents bear a significant burden for the care of their child with CCHS including provision of NIV at home, close monitoring, and regular surveillance for complications. Information about patients with CCHS comes from databases in the United States and Europe, but these don't include infants or children for whom ventilator support was not offered. In this paper we use a case study to explore the ethical issues of provision of treatment, or non-treatment, of children with CCHS.

5 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023114
2022173
202173
202071
201949
201860