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Hypoventilation

About: Hypoventilation is a research topic. Over the lifetime, 1772 publications have been published within this topic receiving 40799 citations. The topic is also known as: respiratory depression.


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Journal ArticleDOI
01 Feb 2009-Chest
TL;DR: A Chinese family with paired-like homeobox 2B (PHOX2B) mutation-confirmed CCHS is reported, with a clinical spectrum from newborn to adulthood, to increase awareness of its various manifestations.

33 citations

Journal ArticleDOI
TL;DR: A 6‐year‐old girl who had subacute onset of hypoventilation and apnea during sleep and died two years later during sleep had a ganglioneuroma originating in the sympathetic ganglia, and all‐night polysomnographic studies revealed frequent obstructive and central sleep apnea episodes.
Abstract: A 6-year-old girl had subacute onset of hypoventilation and apnea during sleep. Diffuse dysautonomic changes were identified, including dilated, nonreactive pupils, decreased tearing and sweating, and abnormal temperature and cardiovascular control. All-night polysomnographic studies revealed frequent obstructive and central sleep apnea episodes. Her serum contained cytotoxic antineuroblastoma immunoglobulins. She died two years later during sleep. The general pathological examination revealed a ganglioneuroma originating in the sympathetic ganglia. Abnormalities in the brain were confined to the brainstem and consisted of complete loss of neurons with severe fibrillary gliosis in the region of the Edinger-Westphal nuclei as well as loss of neurons with gliosis in the locus ceruleus and in the reticular formation bilaterally.

32 citations

Journal ArticleDOI
TL;DR: Sleep disordered breathing, including hypoventilation, was common in patients with DS and the obstructive component increased significantly with age and BMI, while the central component occurred most in the very young age group.
Abstract: Patients with Down syndrome (DS) are at risk for both obstructive sleep apnea (OSA) and central sleep apnea (CSA); however, it is unclear how these components evolve as patients age and whether patients are also at risk for hypoventilation. A retrospective review of 144 diagnostic polysomnograms (PSG) in a tertiary care facility over 10 years was conducted. Descriptive data and exploratory correlation analyses were performed. Sleep disordered breathing was common (seen in 78% of patients) with an average apnea-hypopnea index (AHI) = 10. The relative amount of obstructive apnea was positively correlated with age and body mass index (BMI). The relative amount of central sleep apnea was associated with younger age in the very youngest group (0–3 years). Hypoventilation was common occurring in more than 22% of patients and there was a positive correlation between the maximum CO2 and BMI. Sleep disordered breathing, including hypoventilation, was common in patients with DS. The obstructive component increased significantly with age and BMI, while the central component occurred most in the very young age group. Due to the high risk of hypoventilation, which has not been previously highlighted, it may be helpful to consider therapies to target both apnea and hypoventilation in this population.

32 citations

Journal ArticleDOI
TL;DR: These etiologies, the evidence, and pathophysiology supporting the hypothesis that infarction of segments of ribs by the same vaso-occlusive process responsible for the acute episodes of pain (characteristic of the sickle cell diseases) is often involved in the acute chest structure are summarized.
Abstract: The acute chest syndrome is a generic term for pulmonary complications of sickle cell diseases with heterogeneous etiologies that include pneumonia, vaso-occlusion of pulmonary arterioles, rib infarction, and fat embolism syndrome. My review summarizes these etiologies, the evidence, and pathophysiology supporting the hypothesis that infarction of segments of ribs by the same vaso-occlusive process responsible for the acute episodes of pain (characteristic of the sickle cell diseases) is often involved in the acute chest structure. Inflammation associated with the infarct then causes splinting, hypoventilation, and hypoxia and further vaso-occlusion. The relationship with adult respiratory distress syndrome and fat embolism is also discussed. Use of the incentive spirometer combined with effective analgesia when chest pain is present is advocated for prevention of the pulmonary infiltrates. Newer understanding of the role of nitric oxide in regulating oxygen transport and its relationship to blood transfusions used in therapy of the acute chest syndrome are discussed.

32 citations

Journal ArticleDOI
TL;DR: Both hypoventilation and myoclonus were suppressed for 4 years with L-5-hydroxytryptophan and carbidopa in a patient with a syndrome of progressive myOClonus, ataxia, central neurogenic hypovENTilation, mental retardation, motor neuropathy, and morphologic mitochondrial abnormalities in skeletal muscle.
Abstract: Both hypoventilation and myoclonus were suppressed for 4 years with L-5-hydroxytryptophan and carbidopa in a patient with a syndrome of progressive myoclonus, ataxia, central neurogenic hypoventilation, mental retardation, motor neuropathy, and morphologic mitochondrial abnormalities in skeletal muscle.

32 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023114
2022173
202173
202071
201949
201860