Topic
Hypoventilation
About: Hypoventilation is a research topic. Over the lifetime, 1772 publications have been published within this topic receiving 40799 citations. The topic is also known as: respiratory depression.
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TL;DR: Diagnosis of OHS is more delayed in women and as a consequence the disease is more advanced when diagnosed and in spite of this, there is no gender difference in survival rate in patients with OHS treated with LTMV.
31 citations
Journal Article•
TL;DR: The majority of the symptoms of hypoventilation rapidly disappeared with nocturnal ventilation and the daytime PaO2 and PaCO2 improved significantly allowing the patients to perform more daily activities.
Abstract: 29 patients with chronic respiratory failure due to neuromuscular deficits and restrictive chest wall disorders were treated with nocturnal ventilation via nasal mask at home for at least one year. Home ventilation was provided by a volume cycled positive pressure ventilator attached to a nasal mask which was made to measure by modelling silicon paste onto the patient's face. This method was well tolerated. The majority of the symptoms of hypoventilation rapidly disappeared with nocturnal ventilation and the daytime PaO2 and PaCO2 improved significantly allowing the patients to perform more daily activities. Nocturnal nasal ventilation is efficient but needs strict supervision. The nasal mask can replace or postpone tracheostomy which, if needed, remains a possible and efficient method.
31 citations
TL;DR: In this article, the authors found that moderate hypercapnia powerfully depresses flexor withdrawal responses to noxious stimuli, by a mechanism involving release of endogenous opioids but not systemic catecholamines, which may account in part for the elevation in pain threshold during hypoventilation.
31 citations
TL;DR: Treatment for obstructive sleep apnea syndrome includes continuous positive airway pressure and its variants, oral appliances, weight loss, upper airway surgery, and rarely maxillofacial procedures.
Abstract: Obstructive sleep apnea syndrome (OSAS) is a common disorder characterized by repetitive episodes of breathing cessation due to complete or partial collapse of the upper airway therefore affecting ventilation. It is quite common, with a prevalence of about 2-4%, has a strong genetic component, and creates a proinflammatory state with elevated TNFα and other cytokines. If untreated, OSA can lead to significant neurological problems that include stroke, cognitive decline, depression, headaches, peripheral neuropathy, and nonarteritic ischemic optic neuropathy (NAION). Treatment reverses some of these neurological problems. Treatment includes continuous positive airway pressure and its variants, oral appliances, weight loss, upper airway surgery, and rarely maxillofacial procedures. Other sleep breathing disorders such as hypoventilation, central sleep apnea, complex sleep apnea, and Cheyne-Stokes respiration are less common and are sometimes associated with neuromuscular disorders causing diaphragmatic paralysis, but can also be seen in opiate exposure and severe obesity.
31 citations
TL;DR: Diaphragm pacing was used for treating 6 infants with congenital hypoventilation syndrome at the Children's Memorial Hospital, Chicago with results comparable to those reported in adults.
30 citations