Topic
Hypoventilation
About: Hypoventilation is a research topic. Over the lifetime, 1772 publications have been published within this topic receiving 40799 citations. The topic is also known as: respiratory depression.
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TL;DR: The clinical presentation of CCHS is presented, the results of human physiologic studies are revisited, and new evidence suggests the RTN may be the respiratory controller where chemoreceptor inputs are integrated.
27 citations
TL;DR: In man the hypoventilation that follows a period of hyperventilation can result in a definite lowering of arterial oxygen tension if air is breathed after operation, and in patients subjected tohyperventilation spontaneous breathing began when arterial carbon dioxide tension rose from 18 to 38 mm of mercury.
Abstract: In 13 patients, free of cardiopulmonary disease, who had been subjected to hyperventilation for an average of two and three-quarters hours during anesthesia and operation, spontaneous breathing began when arterial carbon dioxide tension rose from 18 to 38 mm of mercury Thereafter the patients were allowed to breathe air Tidal volume and minute volume increased progressively throughout the first postoperative hour while arterial carbon dioxide tension varied less than 2 mm of mercury Twenty minutes after the onset of spontaneous breathing, arterial oxygen tension reached an average low value of 72 mm of mercury and then progressively increased toward normal, averaging 83 mm at 30 minutes and 88 mm at 60 minutes Thus, in man the hypoventilation that follows a period of hyperventilation can result in a definite lowering of arterial oxygen tension if air is breathed after operation Yet this hypoventilation was associated with a normal arterial carbon dioxide tension Carbon dioxide tension is no
27 citations
TL;DR: Because of its high mortality and morbidity, the possibility of ROHHAD syndrome needs to be considered in all pediatric cases of early- and rapid-onset obesity associated with hypothalamic-pituitary endocrine dysfunction.
Abstract: A very rare syndrome of rapid-onset obesity with hypoventilation, hypothalamic dysfunction and autonomic dysregulation (ROHHAD) has been recently described as causing morbidity due to hypothalamic dysfunction and respiratory arrest. Its prognosis is poor and often cardiac arrest occurs due to alveolar hypoventilation. This disorder can mimic genetic obesity syndromes and several endocrine disorders. We present a 13-year-old female patient who was reported to be healthy until the age of 3 years. She was admitted to our emergency department, presenting with respiratory distress. Features matching ROHHAD syndrome such as rapid-onset obesity, alveolar hypoventilation, central hypothyroidism, hyperprolactinemia, Raynaud phenomenon and hypothalamic hypernatremia were detected in the patient. In addition to these features, the patient was found to have hypergonadotropic hypogonadism and megaloblastic anemia. Because of its high mortality and morbidity, the possibility of ROHHAD syndrome needs to be considered in all pediatric cases of early- and rapid-onset obesity associated with hypothalamic-pituitary endocrine dysfunction.
27 citations
TL;DR: Sleep disordered breathing is highly prevalent in adult DM1 patients complaining of daytime sleepiness, and non-invasive ventilation significantly, rapidly and persistently improves nocturnal gas exchange.
27 citations
TL;DR: The experience supports an autoimmune pathogenesis and provides the first neuropsychological profile of patients with rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation.
Abstract: Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD) is a rare, generally progressive, and potentially fatal syndrome of unclear etiology. The syndrome is characterized by normal development followed by a sudden, rapid hyperphagic weight gain beginning during the preschool period, hypothalamic dysfunction, and central hypoventilation, and is often accompanied by personality changes and developmental regression, leading to substantial morbidity and mortality. We describe 2 children who had symptomatic and neuropsychological improvement after high-dose cyclophosphamide treatment. Our experience supports an autoimmune pathogenesis and provides the first neuropsychological profile of patients with rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation.
26 citations