Topic
Hypoventilation
About: Hypoventilation is a research topic. Over the lifetime, 1772 publications have been published within this topic receiving 40799 citations. The topic is also known as: respiratory depression.
Papers published on a yearly basis
Papers
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TL;DR: With appropriate use of ventilator strategies, a reduction in the mortality and morbidity of patients with obstructive airway disease requiring mechanical ventilation has recently been noted.
25 citations
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TL;DR: To further understand PWS several mutant mice, in which each candidate gene has been separately inactivated, have been developed and shown variable symptoms depending on the genes inactivated; among them the Necdin deficiency appears to be responsible for breathing disorders.
25 citations
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TL;DR: After 3 to 6 months of nasal continuous positive airway pressure (CPAP) treatment, the QOL in OHS improved to the normal level similar to the two other OSA groups, and one of the risk factors seems to be a small craniomandibular structure, which could induce an increase in upper airway resistance during sleep.
Abstract: The first paper of this issue of Sleep and Breathing reports that the quality of life (QOL) assessed by the SF-36 and the Epworth Sleepiness Scale (ESS) in obesity hypoventilation syndrome (OHS) was compared with age- and body mass index-matched patients without hypoventilation (obese OSA), nonobese OSA patients, and healthy subjects. The QOL in OHS was worst among these four groups. After 3 to 6 months of nasal continuous positive airway pressure (CPAP) treatment, the QOL in OHS improved to the normal level similar to the two other OSA groups. We have observed severe nonobese OSA patients with hypoventilation. One of the risk factors, which related to a severe general condition, seems to be a small craniomandibular structure, which could induce an increase in upper airway resistance during sleep. Characteristics of Japanese OSA patients may be different from those in other countries. Although belatedly, the clinical study and management of sleep disordered breathing have just begun.
25 citations
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TL;DR: In this paper, the relative importance of arterial oxygen tension and hydrogen ion concentration in regulating pulmonary arterial pressure was evaluated in a 43-year-old woman with hypoventilation and obesity.
Abstract: The relative importance of arterial oxygen tension and hydrogen ion concentration in regulating pulmonary arterial pressure was evaluated in a 43-year-old woman with hypoventilation and obesity. It was shown that hydrogen ion concentration played a dominant role in the regulation of her pulmonary circulation.
25 citations
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TL;DR: The generation of mouse models of CCHS provides tools for evaluating treatments aimed at alleviating both the respiratory symptoms and all other autonomic symptoms of C CHS.
25 citations