Imaging technology

About: Imaging technology is a research topic. Over the lifetime, 1450 publications have been published within this topic receiving 26186 citations.

High-spatial-resolution laser spectral-pupil differential confocal mass spectrum microscopic imaging method and device

Abstract: The invention relates to a high-spatial-resolution laser spectral-pupil differential confocal mass spectrum microscopic imaging method and device and belongs to the field of confocal microscopic imaging technologies and mass spectrum imaging technologies. The spectral-pupil differential confocal microscopic imaging technology and the mass spectrum imaging technology are combined, a sample is axially focused and imaged through the focused spot of a high-spatial-resolution spectral-pupil differential confocal microscopic system, the same focused spot of the high-spatial-resolution spectral-pupil differential confocal microscopic system is utilized to desorb and ionize the sample for mass spectrum imaging, and further the high-spatial-resolution imaging of images and compositions of a micro area of the sample is realized. The method and the device can realize high-spatial-resolution mass spectrum detection and mirco-area microscopic imaging, effectively release the high-spatial-resolution potential of the spectral-pupil differential confocal system, improve the spatial resolving power of a laser mass spectrometer, and have strong resistance to stray light. The method and the device can provide a new effective technical way for biomass spectrum high-resolution imaging.

Autofluorescence Image Reconstruction and Virtual Staining for In-Vivo Optical Biopsying

Abstract: Modern photonic technologies are emerging, allowing the acquisition of in-vivo endoscopic tissue imaging at a microscopic scale, with characteristics comparable to traditional histological slides, and with a label-free modality. This raises the possibility of an ‘optical biopsy’ to aid clinical decision making. This approach faces barriers for being incorporated into clinical practice, including the lack of existing images for training, unfamiliarity of clinicians with the novel image domains and the uncertainty of trusting ‘black-box’ machine learned image analysis, where the decision making remains inscrutable. In this paper, we propose a new method to transform images from novel photonics techniques (e.g. autofluorescence microscopy) into already established domains such as Hematoxilyn-Eosin (H-E) microscopy through virtual reconstruction and staining. We introduce three main innovations: 1) we propose a transformation method based on a Siamese structure that simultaneously learns the direct and inverse transformation ensuring domain back-transformation quality of the transformed data. 2) We also introduced an embedding loss term that ensures similarity not only at pixel level, but also at the image embedding description level. This drastically reduces the perception distortion trade-off problem existing in common domain transfer based on generative adversarial networks. These virtually stained images can serve as reference standard images for comparison with the already known H-E images. 3) We also incorporate an uncertainty margin concept that allows the network to measure its own confidence, and demonstrate that these reconstructed and virtually stained images can be used on previously-studied classification models of H-E images that have been computationally degraded and de-stained. The three proposed methods can be seamlessly incorporated on any existing architectures. We obtained balanced accuracies of 0.95 and negative predictive values of 1.00 over the reconstructed and virtually stained image-set on the detection of color-rectal tumoral tissue. This is of great importance as we reduce the need for extensive labeled datasets for training, which are normally not available on the early studies of a new imaging technology.

CHAPTER 3 – Evolution of Clinical Emission Tomography

Abstract: This chapter discusses the historical development of Emission Tomography (ET) and its clinical applications. It first discusses the beginnings of nuclear medicine imaging and recalls some of the history, experience, and theoretical developments that guided the development of the technology. Emission tomography has made it possible to increase the visibility of low-contrast structures and provides quantitative information on the structure, uptake, turnover, and metabolic properties of biological systems, along with the pharmacokinetic behavior of radiolabeled drugs. Emission tomography has made it possible to move seamlessly from destructive 3D studies in animals to noninvasive nuclear imaging procedures in humans that are enhancing knowledge in many areas of medicine. The development of new imaging technology has revolutionized the diagnostic and therapeutic processes. The understanding of biochemical pathways and physiological processes was the first focus of nuclear medicine research. Furthermore, this chapter discusses the role of ET in several areas such as, brain imaging, thyroid imaging, cardiac imaging, kidney imaging, lung imaging, bone imaging, reticuloendothelial system, imaging tumor, and imaging molecular biology.

Large view field optical imaging system based on computing imaging technology

Abstract: Provided is a large view field optical imaging system based on a computing imaging technology. An imaging system structure of a shared primary mirror, a micro lens array and a detector array is adopted. Incident light respectively passes through the shared primary mirror and the micro lens array and finally reaches the detector array to perform imaging, image restoration (removing influence of spherical aberration on image quality) is performed on each subimage through the computing imaging technology, and a whole clear image can be obtained after registering compositing is performed on each subimage. The shared primary mirror is a single core sphere mirror composed of two semisphere mirrors. The whole optical imaging system is simple in structure, fully symmetrical and easy to process, install and test, has the advantages of extra large view field and low structural complexity and the like, and is particularly suitable for large-range search of space targets and stratosphere air surveillance and the like.

Novel Imaging Modalities for Human Embryology and Applications in Education.

Abstract: Advances in imaging technology and development have recently enabled high-resolution three-dimensional (3D) imaging of embryos and fetuses. Embryos and fetuses stored at the Congenital Anomaly Research Center (Kyoto Collection of Human Embryos, Kyoto, Japan) were imaged using multiple modalities including magnetic resonance imaging, episcopic fluorescence image capture, and X-ray computed tomography, both in absorption and phase-contrasted configurations. Using the acquired images, 3D computer graphics were generated and a movie was created to gain further insight into understanding the developmental process. For educational purposes, self-learning materials were also produced. The present review article briefly discusses each project and the results of imaging studies performed using specimens from the Kyoto Collection of Human Embryos. Anat Rec, 301:1004-1011, 2018. © 2018 Wiley Periodicals, Inc.