Showing papers on "Indole alkaloid published in 1988"

Synthesis of the hexacyclic indole alkaloid (.+-.)-kopsijasmine

Abstract: Synthese a partir de chloro-2 iodo-3 propene et de p-methoxybenzenesulfonyl-6 phenylthio-11 hexahydro-2,3,6,10b,11,12 indolizino [8,1-cd] carbazolone-12 via un derive de chloro-3 kopsane

Rhazya stricta Decaisne: In Vitro Culture, and the Production of Indole Alkaloids

Abstract: Rhazya stricta Decaisne (Apocynaceae) is characterized by its high contents of certain indole alkaloids (Chatterjee et al. 1974). This plant (Fig. 1) has been used to cure fever, sore throat, and chronic rheumatism (Mariee 1983). Recent pharmacological studies indicated that these indole alkaloids can also be used as antitumor agents (Mukhopadhyay et al. 1981).

Monoterpene Indole Alkaloids from Apocynaceae other than Catharanthus roseus

Abstract: Publisher Summary The monoterpene indole alkaloids represent a large and diverse group of plant products, the majority of which have been isolated from species belonging to three families—the Loganiaceae, Apocynaceae, and Rubiaceae This chapter reviews the indole alkaloid production by cultured plant cells derived from species of genera other than Catharanthus and Cinchona The monoterpene indole alkaloids are derived from a unit of tryptamine and a C9/C10 unit of terpenoid origin The basis of their classification rests on the geometric arrangement of the C9/C10 carbon skeleton with the three main configurations being categorized as the Corynanthe, Aspidosperma, and Ibogatypes There is another group of alkaloids, the bisindole group, which is a large and diverse array of structures arising from the union of two monomeric indole alkaloids The complexity of these types of alkaloids is not only because the monomers of which they are composed of but also because of the manner in which the monomers are linked

Leurosinone: a new binary indole alkaloid from Catharanthus roseus

Abstract: A new binary indole alkaloid, leurosinone, has been isolated from the leaves of Catharanthus roseus, and has been assigned structure (1) on the basis of spectral studies.

The lipid composition and conversion of tryptamine to Nb-acetyltryptamine in a Catharanthus roseus cell line without indole alkaloids

Abstract: A cell line, NA13-2, was selected as a rapidly growing colony of protoplasts from a UV(254 nm)-fluorescent cell line, NA13-1, which originated from a tryptamine-resistant strain ofCatharanthus roseus NA13. Cell line NA13-2 lost the capability to produce indole alkaloids. Tryptophan fed to these cells was converted toN b-acetyltryptamine as the major product. The free acetyl coenzyme A content of NA13-2 cells was 50% higher than in the mother cells. The total lipid content of the NA13-2 cells was 2.5-fold that in the NA13 cells. In spite of the similarity in the fatty acid content to that of the mother cell line NA13, the total lipid extract of NA13-2 cells appeared as a wax instead of an oil, resulting from the presence of sterol esters.

Production of physiologically active substance

Abstract: PURPOSE: To produce a physiologically active substance such as indole alkaloid by the tissue culture of a plant of genus Lochnera in a medium containing one or more components selected from Ca, Zn, I 2 , inositol, nicotinic acid, pyridoxine, etc CONSTITUTION: A physiologically active substance is produced by cloturing a plant of genus Lochnera in a medium containing 0-1mM of Ca, 0-10μM of Zn, 0-2μM of iodine, 02-20g/l of inositol, 0-03mg/l of nicotinic acid, 0-03mg/l of pyridoxine and 0-1mg/l of glycine The plant of genus Lochnera to be cultured is preferably Catharanthus roseus var Little Bright Eye A concrete example of the physiologically active substance is indole alkaloid COPYRIGHT: (C)1990,JPO&Japio

Cultivated Plant Cells: An Enzyme Source for Alkaloid Formation

Abstract: Plant cell cultures have been proved in the past to be an efficient source for the isolation of novel enzymes. Therefore, cultivated plant cells are a valuable tool fur the investigation of the biosynthesis of secondary metabolites. Three examples in the alkaloid field are discussed: the enzymatic formation of the isoquinoline alkaloid berberine in the family Berberidaceae, the biosynthesis of the indole alkaloid ajmaline in Rauwolfia serpentina Benth. and the in vitro preparation of the dimeric alkaloids voafrine A and B.

Structure-activity studies of indole alkaloid tumor promoters

Abstract: Carcinogenic promoters produced by microorganisms were sought using the Epstein-Barr virus early antigen (EBV-EA) induction test, a short-term promoter test system, and one strain, SIJ'tPlorJeTticWium

Alkaloid Production from Cinchona Cell and Organ Systems

Abstract: Alkaloids from members of the genus Cinchona are important because they are used for antimalarial and antiarrhythmic therapy, and as a beverage bitter. In vitro cultures of species such as Cinchona ledgeriana and C. pubescens are being studied in various laboratories for their production of indole alkaloids, quinoline alkaloids, and anthraquinones, and for use as a micropropagation system. The extent to which cell and organ systems express the quinoline alkaloids quinine and quinidine and how their production is affected by growth regulators, differentiation and morphology, and alkaloid intermediates will be discussed. Examples of alkaloid intermediates to be considered are tryptophan, secologanin, strictosidine (isovincoside), 10-methoxystrictosidine, vincoside, and 10-methoxyvincoside.

A Directed Metalation Route to the Zwitterionic Indole Alkaloids. Synthesis of Sempervirine.

Abstract: A synyhesis protocol involving beta-lithiation of 2-(2-pyridinyl)indoles (4 → 5) and subsequent reaction with bromoacetaldehyde leads to the indol[2,3-a]quinolzine(1)ring system. Application of this methodology to 2-(2-pyridinyl)indole 17, which is prepered via Taylor-Boger triazine Dieis-Alder annulation chemistry, affords the zwitterionic indole alkaloid sempervirine (3).