Showing papers on "Indole alkaloid published in 1989"
TL;DR: In this paper, the marine indole alkaloid derivative N(10)-acetyleudistomin L has been prepared in a convergent synthesis, starting from 5-bromoindole and L-cysteine.
31 citations
31 citations
28 citations
TL;DR: Synthese de (-)- et (+)-1,2,3,5,6,11bhexahydro indolizino[8,7b] indole-11b-carboxylates de methyle a partir de tryptophane et d'α-cetoglutarate de dimethyle.
Abstract: Synthese de (-)- et (+)-1,2,3,5,6,11b-hexahydro indolizino[8,7-b] indole-11b-carboxylates de methyle a partir de tryptophane et d'α-cetoglutarate de dimethyle
19 citations
TL;DR: More than 100 indole alkaloids have been isolated from the different parts of the plant, many of them with important pharmacological activity as discussed by the authors, including antileukemic drugs vinblastine and vincristine.
Abstract: Catharanthus roseus (L.) G. Don, Madagascan periwinkle, is a well-known medicinal herb on which a lot of research has been done, especially on isolation and conversion of its alkaloids. To date more than 100 indole alkaloids have been isolated from the different parts of the plant, many of them with important pharmacological activity (1–3). The most notable of these therapeutic alkaloids are the antileukemic drugs vinblastine (1) and vincristine (2), the antihypertensive ajmalicine (3) used in combination with reserpine, and serpentine (4) which has a sedative effect. The generally low concentration of these products in a plant which is itself scarce, combined with the difficulty of separating the valuable alkaloids from others co-occurring ones, has encouraged intensive research on their synthesis or semisynthesis (4–11). So far, however, attempts to produce these alkaloids economically by the normal methods of synthetic organic chemistry have not given satisfactory results.
19 citations
TL;DR: A new indole alkaloid, murrayacarine together with 13 known compounds, 3-formylindole, omphalocarpin, 5,7-dimethoxy-8-(3′-methyl-2′-oxobutyl) coumarin, coumurrayin, murragleininin, mupanidin, mexoticin and murrangatin, and ferulyl esters were characterized on the basis of spectral analysis as discussed by the authors.
17 citations
TL;DR: The first total synthesis of the Strychnos indole alkaloid 19,20-dihydroakuammicine and detailed 1H- and 13C-NMR data of this alkalinoid were reported in this article.
11 citations
TL;DR: A quaternary indole alkaloid, venecurine, has been isolated by chromatographie techniques from a curare obtained from the Hoti tribe of Venezuela as mentioned in this paper.
8 citations
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