scispace - formally typeset
Search or ask a question
Topic

Indole alkaloid

About: Indole alkaloid is a research topic. Over the lifetime, 868 publications have been published within this topic receiving 15401 citations. The topic is also known as: indole alkaloids.


Papers
More filters
Book ChapterDOI
01 Jan 2014
TL;DR: In this review, intra- and intercellular compartmentation of the monoterpenoid indole alkaloid (MIA) pathway in Catharanthus roseus and TPT2 transporter families possibly involved in MIA secretion in all MIA active plant species are discussed.
Abstract: Alkaloids are a large and diverse group of natural compounds that are related by the occurrence of a nitrogen atom within a heterocyclic backbone. Due to their strong and divergent biological activities, some of them are applied for clinical uses. Alkaloids are often highly accumulated in particular sites in plants and are often translocated from source tissue/organ to “sink” tissue/organ. Accordingly the complex development-, environment-, organ-, and cell-specific expression of pathway genes include the trafficking of biosynthetic intermediates between different organelles and also their movement between different cell types. Recently the involvement of ABC transporters in alkaloid translocation has been documented thus beginning an interesting new phase in the description of the biochemical components that are required for alkaloid biosynthesis. The identification of these alkaloid transporters is helping to better understand how intra- and inter-cellular compartmentation play important roles in the production/accumulation of alkaloids and supplies new approaches for engineering alkaloid production by manipulating pathway intermediate transport. As an important medicinal plant, Catharanthus roseus remains the only source of the anticancer drugs vinblastine and vincristine where it accumulates at very low levels, even if their catharanthine- and vindoline-building blocks are much more abundant. The in planta biosynthesis of these compounds is very complex involving several different organelles and cell types. Recently, a new ATP-binding cassette (ABC) transporter, CrTPT2, has been identified that controls catharanthine secretion to leaf surface from leaf epidermis where catharanthine biosynthesis occurs. In this review, we discuss intra- and intercellular compartmentation of the monoterpenoid indole alkaloid (MIA) pathway in Catharanthus roseus and TPT2 transporter families possibly involved in MIA secretion in all MIA active plant species.

5 citations

Journal ArticleDOI
TL;DR: A new indole alkaloid of the pyridocarbazole type and two known compounds, 2N-oxide-olivacine and olivacine, were isolated from roots of Peschiera affinis.
Abstract: A new indole alkaloid of the pyridocarbazole type, named 6N-hydroxy-olivacine, and two known compounds, 2N-oxide-olivacine and olivacine, were isolated from roots of Peschiera affinis. The structures of the compounds were determined by spectroscopic {IR and extensive NMR (COSY, HMQC, HMBCand NOESY)} and EIMS analysis.

5 citations

Journal ArticleDOI
TL;DR: A new type of Gelsemium alkaloid, 11-methoxygelsemamide (2), having a 1,2-secoindole system, was synthesized for the first time from a sarpagin this article.

5 citations


Network Information
Related Topics (5)
Absolute configuration
7.8K papers, 124.7K citations
90% related
Triterpene
4.1K papers, 81.1K citations
89% related
Glycoside
4.6K papers, 80.8K citations
88% related
Indole test
19.9K papers, 318K citations
88% related
Isoquinoline
5.8K papers, 68.6K citations
88% related
Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202329
202254
202133
202029
201923
201828