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Indole alkaloid

About: Indole alkaloid is a research topic. Over the lifetime, 868 publications have been published within this topic receiving 15401 citations. The topic is also known as: indole alkaloids.


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Journal ArticleDOI
01 Jan 2020-Synlett
TL;DR: In this article, the first asymmetric total synthesis of the macroline-type indole alkaloid (−)-Alstofolinine A. A. was synthesized using the aza-Achmatowicz reaction and nucleophilic addition reaction cascade.
Abstract: Indole-fused tetracyclic ring systems containing nitrogen atoms are common core skeletons of many indole alkaloids such as sarpagine, macroline, and ajmaline. Efficient and stereoselective construction of these ring systems can promote the development of the corresponding alkaloid syntheses. In this article, we briefly summarize our current progress toward the application of the aza-Achmatowicz reaction and indole nucleophilic addition reaction cascade for the first asymmetric total synthesis of the macroline-type indole alkaloid (–)-Alstofolinine A. Our synthetic strategy is based on furan oxidation/rearrangement and proceeds from easily accessible materials such as indole and furan derivatives.

5 citations

Journal ArticleDOI
TL;DR: In spite of the similarity in the fatty acid content to that of the mother cell line NA13, the total lipid extract of NA13-2 cells appeared as a wax instead of an oil, resulting from the presence of sterol esters.
Abstract: A cell line, NA13-2, was selected as a rapidly growing colony of protoplasts from a UV(254 nm)-fluorescent cell line, NA13-1, which originated from a tryptamine-resistant strain ofCatharanthus roseus NA13. Cell line NA13-2 lost the capability to produce indole alkaloids. Tryptophan fed to these cells was converted toN b-acetyltryptamine as the major product. The free acetyl coenzyme A content of NA13-2 cells was 50% higher than in the mother cells. The total lipid content of the NA13-2 cells was 2.5-fold that in the NA13 cells. In spite of the similarity in the fatty acid content to that of the mother cell line NA13, the total lipid extract of NA13-2 cells appeared as a wax instead of an oil, resulting from the presence of sterol esters.

4 citations

Journal ArticleDOI
TL;DR: The structure of 3-hydroxyvoachalotine, a new indole alkaloid isolated from the root bark of Voacanga chalotiana, has been determined by spectroscopic analysis and by chemical correlation with voachAlotine.

4 citations

Journal ArticleDOI
TL;DR: The marine indole alkaloid villagorgin A was synthesized by reduction and cyclization of an indolylethylimidazopyridinium salt by oxidation with mercuric acetate.
Abstract: The marine indole alkaloid villagorgin A was synthesized by reduction and cyclization of an indolylethylimidazopyridinium salt. Its oxidation with mercuric acetate gave villagorgin B.

4 citations

Journal ArticleDOI
TL;DR: One undescribed indole alkaloid together with twenty-two known compounds have been isolated from aerial parts of Vinca minor L. (Apocynaceae) as discussed by the authors .

4 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202329
202254
202133
202029
201923
201828