Topic
Indole alkaloid
About: Indole alkaloid is a research topic. Over the lifetime, 868 publications have been published within this topic receiving 15401 citations. The topic is also known as: indole alkaloids.
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TL;DR: The isolation and structural determination of aristofruticosine (1), an alkaloid with a unique 3-azatricyclo[3.3.1.03,7]nonane nucleus, is described in this paper.
4 citations
TL;DR: In this article, the precondylocarpinetype pentacyclic skeleton and a two-carbon unit were considered for 24 alkaloids having the precONDYLOCCARPINETE this article.
Abstract: In this review we consider 24 alkaloids having the precondylocarpinetype pentacyclic skeleton and a two-carbon unit (carbons 18 and 19 in the “biogenetic numbering” of Le Men and Taylor (1)). All can be derived from precondylocarpine (1) via condylocarpine (2). To date, no comprehensive review of these alkaloids has appeared. However, considerable information can be found in M Hesse’s (2) Tables of Indole Alkaloids under the aspidospermatine-type alkaloids. Husson (3) has recently reviewed Strychnos alkaloids discovered or studied in the seventies and up to 1982. Besides the chemical and structural properties he notes plant sources of condylocarpine derivatives. Van Beek et al. (4) have listed the alkaloids isolated from the genus Tabernaemontana.
4 citations
TL;DR: In this paper, the chiral total synthesis of mitragynine, a major corynanthe-type indole alkaloid having an analgesic effect in Mitragyna speciosa, was accomplished.
Abstract: Starting from an optically pure alcohol, (R)-(3), which was prepared by enzymatic hydrolysis of the racemic acetate (2) or enantioselective reduction of the ketone derivative (4), the chiral total synthesis of mitragynine (1), a major corynanthe-type indole alkaloid having an analgesic effect in Mitragyna speciosa, was accomplished.
4 citations
TL;DR: In this paper, a short total synthesis of crooksidine and demethoxycarbonyltetrahydrosecodine is described, and the synthesis is shown to be possible.
Abstract: A short total synthesis of crooksidine and demethoxycarbonyltetrahydrosecodine is described.
4 citations
TL;DR: A structurally unprecedented prenylated indole alkaloid, beshanzuamide A (1), together with five known analogues (2, 6) were isolated and identified from the endophytic fungus derived from the needles of the critically endangered conifer Abies beshaneensis as discussed by the authors .
Abstract: A structurally unprecedented prenylated indole alkaloid, beshanzuamide A (1), together with five known analogues (2–6) were isolated and identified from the endophytic fungus derived from the needles of the critically endangered conifer Abies beshanzuensis. The new structure was determined by extensive spectroscopic methods and quantum chemical calculations of NMR and electronic circular dichroism (ECD) data. Compound 1 features a unique N,O-spiroketal/δ-lactone motif connected to a pyranoindole-derived bicyclo[2.2.2]diazaoctane ring. A plausible biogenetic pathway for the assembly of 1 was proposed.
4 citations