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Indole alkaloid

About: Indole alkaloid is a research topic. Over the lifetime, 868 publications have been published within this topic receiving 15401 citations. The topic is also known as: indole alkaloids.


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Patent
04 Nov 2015
TL;DR: In this paper, the indole alkaloid has a good anti-tumor effect on gastric cancer and plays a certain role on liver cancer and breast cancer and is to become a novel anti-Tumor drug in the market.
Abstract: The invention discloses indole alkaloid and application thereof and belongs to the technical field of medicines. The structural formula of the indole alkaloid is shown in the description. Experimental data verify that the indole alkaloid has a good anti-tumor effect on gastric cancer and plays a certain role on liver cancer and breast cancer. The compound has the advantages of high efficiency and low toxicity and is to become a novel anti-tumor drug in the market.

2 citations

01 Jan 2017
TL;DR: The construction of a robust and efficient alternative production platform in C. roseus hairy roots by manipulating the TIA pathway has become a promising strategy in recent years and recent advances in high-throughput sequencing technology have greatly sped up the elucidation of the Tia pathway.
Abstract: Catharanthus roseus (Madagascar periwinkle) produces many pharmaceutically important chemicals such as vinblastine, vincristine, serpentine, and ajmalicine. They are synthesized through the highly branched and complex terpenoid indole alkaloid (TIA) pathway in C. roseus. Among the compounds produced in this pathway, vinblastine and vincristine are efficient anticancer drugs widely used in the clinic and are only found in C. roseus. Due to low accumulation of these TIAs within the plant and the infeasibility of production using chemical synthesis at industrial scale, the market price of these drugs remains high. In addition, inconsistent production along with increased demand causes these drugs to often show up on the FDA drug shortage list. With advanced knowledge of molecular biology, metabolic engineering, and bioinformatics, the construction of a robust and efficient alternative production platform in C. roseus hairy roots by manipulating the TIA pathway has become a promising strategy in recent years. In addition, recent advances in high-throughput sequencing technology have greatly sped up the elucidation of the TIA pathway. This review highlights present efforts to discover TIA pathway genes, their compartmentalization, and regulation in C. roseus and summarizes TIA pathway engineering efforts in C. roseus hairy roots.

2 citations

Journal ArticleDOI
TL;DR: In this paper , three monoterpenoid indole alkaloids, gelsevietmines-A, B, C (1, 2), were isolated from Gelsemium elegans seeds collected in Vietnam.

2 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202329
202254
202133
202029
201923
201828