Topic
Indole alkaloid
About: Indole alkaloid is a research topic. Over the lifetime, 868 publications have been published within this topic receiving 15401 citations. The topic is also known as: indole alkaloids.
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24 Jun 2015
TL;DR: In this article, a tetracyclic indole alkaloid derivative was used to inhibit alpha-glucosaccharase for the first time, thereby having a broad prospect in development and application of drugs for treating diabetes; meanwhile, the antineoplastic activity of a synthesized compound on human leukemia cells (K562) and human colon cancer cells (HT-29) is tested in the invention, and the result shows that the IC50 of this kind of derivatives is smaller than 100 uM.
Abstract: The invention relates to a tetracyclic indole alkaloid derivative as well as a preparation method and an application thereof. The structural formula is as follows. The invention finds that the tetracyclic indole alkaloid derivative can well inhibit alpha-glucosaccharase for the first time, thereby having a broad prospect in development and application of drugs for treating diabetes; meanwhile, the antineoplastic activity of a synthesized compound on human hepatoma cells (HepG2), human leukemia cells (K562) and human colon cancer cells (HT-29) is tested in the invention, and the result shows that the IC50 of this kind of derivatives is smaller than 100 uM. Compared with other anti-tumor drugs, the invention finds that the tetracyclic indole alkaloid derivative can kill tumor cells for the first time, and particularly can express good killing efficiency on the human leukemia cells (K562).
2 citations
TL;DR: In this paper, six groups of untransformed and hairy root cultures of Catharunthus roseus (L.) G. Don were established and the highest contents of examined indole alkaloids were found in: roots of intact plants - yohimbine and serpentine; in hairy roots - catharanthine.
Abstract: Six groups of untransformed and hairy root cultures of Catharunthus roseus (L.) G. Don were established. Agrobacterium rhizogenes strains: ATCC 15834, LBA 9403, and TR 105 were used for infection of the 3-week old rooted plantlets of C. roseus . The highest contents of examined indole alkaloids were found in: roots of intact plants - yohimbine and serpentine; in hairy roots - catharanthine. Vinblastine and ajmalicine were detected in untransformed roots of plants regenerated in vitro, and transferred to the soil for 5 months.
2 citations
TL;DR: Two new oxindole alkaloids, rankiniridine (1 ) and humanteniridine(2 ), having a nitrogen-carbon linkage between a humantene-type monoterpenoid indole alkaloid and a monoterpene unit with an iridoid skeleton, were isolated from Gelsemium rankinii and Gelsemia elegans, respectively as discussed by the authors.
Abstract: Two new oxindole alkaloids, rankiniridine ( 1 ) and humanteniridine ( 2 ), having a nitrogen–carbon linkage between a humantenine-type monoterpenoid indole alkaloid and a monoterpene unit with an iridoid skeleton, were isolated from Gelsemium rankinii and Gelsemium elegans , respectively.
2 citations
TL;DR: A new indole alkaloid was isolated from Hosta plantaginea for the first time and showed important inhibition of steroid 5α-reductase activities in vitro.
Abstract: A new indole alkaloid (1), together with eight known indole alkaloid derivatives (2–9), was isolated from Hosta plantaginea for the first time. The structures of compounds 1–9 were elucidated on the basis of comprehensive spectroscopic analyses and references. Compounds 1–9 were evaluated for their inhibition of steroid 5α-reductase activity in vitro. Among them, compounds 1 and 2 showed important inhibition of steroid 5α-reductase activities.
2 citations
2 citations