Topic
Indole alkaloid
About: Indole alkaloid is a research topic. Over the lifetime, 868 publications have been published within this topic receiving 15401 citations. The topic is also known as: indole alkaloids.
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TL;DR: In this paper, an efficient total synthesis of notoamide J, a new prenylated indole alkaloid and potential biosynthetic precursor, is described, starting from l-proline and a substituted tryptophan derivative, also employing an oxidation and pinacol rearrangement for the formation of the oxindole in the final step.
Abstract: An efficient total synthesis of notoamide J, a new prenylated indole alkaloid and potential biosynthetic precursor, is described herein. Starting from l-proline and a substituted tryptophan derivative, this synthesis also employs an oxidation and pinacol rearrangement for the formation of the oxindole in the final step.
2 citations
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TL;DR: The alcoholic extract from the roots of Rauwolfia serpentina Benth afforded a new indole alkaloid which has been identified as 5β-methylpseudoyohimbane by spectroscopic studies as mentioned in this paper.
1 citations
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01 Jan 1982TL;DR: In this paper, the point value for a carboxyl, which is of course (oxy- + oxo-functions) 3, is included even for skeletons which have lost this group during their biosynthesis, since such loss does not imply diminution of oxidation level.
Abstract: The indole alkaloids are outstanding among secondary plant metabolites in their structural intricacy and diversity. Tryptophan and secologanin, through their condensation product vincoside (code I, Table 9.1) as intermediate, are responsible for the biosynthesis of three indole alkaloid groups, characterized by different basic carbon skeletons, the corynanthe (codes prefixed I → V), aspidosperma (codes prefixed VI →, except for VI.3 →), and iboga (codes VI.3 types. The code of each skeleton of the indole alkaloids (Table 9.1) indicates its position on a biogenetic map. Comments on the construction of such maps, as well as their use in the determination of specialization values (S) for skeleta, together with rules for the determination of oxidation values (O) of compounds, are presented in Chapter 6. With reference to the latter topic, the point value for a carboxyl, which is of course (oxy- + oxo-functions) 3, is included even for skeletons which have lost this group during their biosynthesis, since such loss does not imply diminution of oxidation level (cf. Chap. 5).
1 citations
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31 Aug 2016
TL;DR: In this article, a novel indole alkaloid compound with novel structures is reported for the first time and can be obtained by extracting from dried roots of rhizoma corydalis, separating and purifying.
Abstract: The invention discloses novel indole alkaloid compounds as well as a preparation method and medical application thereof. The compounds are reported for the first time and are indole alkaloid compounds with novel structures, and can be obtained by extracting from dried roots of rhizoma corydalis, separating and purifying. In vitro test shows that the compounds can be used for inhibiting the proliferation of a renal cancer cell line RC-2, and the inhibition shows concentration and time dependence; the compounds can be used for being developed into a medicine for treating renal carcinoma.
1 citations
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TL;DR: Actinophyllic acid was found to be a potent inhibitor of the coupled enzyme assay with an IC(50) of 0.84 microM as mentioned in this paper, and the structure of 1 was determined from detailed 2D NMR studies, and it possesses a unique 2,3,6,7,9,13c-hexahydro-1H-1, 7,8-(methanetriyloxymethano)pyrrolo[1',2':1,2]azocino[4,3-b]indole-
Abstract: Bioassay-guided fractionation of the aqueous extract of the leaves of Alstonia actinophylla with use of a coupled enzyme assay, CPU/hippuricase, to detect carboxypeptidase U inhibitors led to the isolation of a novel indole alkaloid, actinophyllic acid (1). The structure of 1 was determined from detailed 2D NMR studies. Actinophyllic acid was found to be a potent inhibitor of the coupled enzyme assay with an IC(50) of 0.84 microM. Actinophyllic acid possesses a unique 2,3,6,7,9,13c-hexahydro-1H-1,7,8-(methanetriyloxymethano)pyrrolo[1',2':1,2]azocino[4,3-b]indole-8(5H)-carboxylic acid skeleton.
1 citations