Topic
Indole alkaloid
About: Indole alkaloid is a research topic. Over the lifetime, 868 publications have been published within this topic receiving 15401 citations. The topic is also known as: indole alkaloids.
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TL;DR: The results indicated that KOK1679 and My295, highly and moderately aphid‐resistant varieties, had a high indole alkaloid content during vegetative growth and during reproduction growth, respectively.
Abstract: Indole alkaloid contents of five winter wheat varieties at different growth stages, and the relationship between indole alkaloids and carboxylesterase activities of Sitobion avenae (F.) from wheat ears of different varieties were studied. The results indicated that KOK1679 and My295, highly and moderately aphid-resistant varieties, had a high indole alkaloid content during vegetative growth. During their reproduction growth, resistant varieties had a high alkaloid content in penultimate leaves, and indole alkaloid contents of KOK1679 were significantly higher than that of other varieties in wheat ears. The indole alkaloid contents of all varieties were low in flag leaves except for Han4564. A significant correlation was shown between carboxylesterase activity in aphids collected from wheat ears and indole alkaloid contents in ears of the wheat varieties (r = 0.9646).
59 citations
TL;DR: Successive fractionation of a crude methanolic extract of cultured PICRALIMA NITIDA cells accompanied by opiate receptor binding studies led to the detection and isolation of two compounds with opioid activity.
Abstract: Successive fractionation of a crude methanolic extract of cultured PICRALIMA NITIDA cells accompanied by opiate receptor binding studies led to the detection and isolation of two compounds with opioid activity. The substances were identified as the indole alkaloids pericalline and pericine, the latter, as yet, not described. Half-maximal inhibition (IC 50 ) by the alkaloids was 2.3 μMol/l for pericalline and 0.6 μMol/l for pericine, values which lie within the micromolar range of the weak analgetic codeine (IC 50 : 3.6 μMol/l).
58 citations
TL;DR: Vindogentianine exhibited potential hypoglycemic activity in β-TC6 and C2C12 cells by inducing higher glucose uptake and significant in vitro PTP-1B inhibition, implying its therapeutic potential against type 2 diabetes.
58 citations
TL;DR: Martefragin A (1), a novel indole alkaloid, showed inhibitory activity on NADPH-dependent lipid peroxidation in rat liver microsomes and the structure of 1 was elucidated on the basis of spectral analysis of its methyl ester.
Abstract: Martefragin A (1), a novel indole alkaloid, was isolated from a red alga, Martensia fragilis, by repeated column chromatography. The structure of 1 was elucidated on the basis of spectral analysis of its methyl ester (2), including 1H- and 13C-NMR, 1H-1H correlation spectroscopy (COSY), and 13-1H COSY. A single crystal X-ray analysis of the hydrochloride of 1 confirmed the assignment. Martefragin A (1) showed inhibitory activity on NADPH-dependent lipid peroxidation in rat liver microsomes. The IC50 values of 1, α-tocopherol and ascorbic acid were 2.8, 87 and 200 μM, respectively.
58 citations
TL;DR: Lotthanongine, a novel flavonoidal indole alkaloid, was isolated from the roots of Trigonostemon reidioides (Euphorbiaceae) together with afzelechin-(4α→8)-afzelechine as mentioned in this paper.
58 citations