Topic
Indole alkaloid
About: Indole alkaloid is a research topic. Over the lifetime, 868 publications have been published within this topic receiving 15401 citations. The topic is also known as: indole alkaloids.
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TL;DR: In this article, two β-carbolines, penipalines A and B (I), and the new indole carbaldehyde derivative, Penipaline C (II), along with two known indole derived analogs from the deep-sea-sediment derived fungus Penicillium paneum SD-44 Compounds (Ib) and (II) exhibit potent cytotoxic activities against A-549 an HCT-116 cell lines.
Abstract: Two new β-carbolines, penipalines A and B (I), and the new indole carbaldehyde derivative, penipaline C (II) are isolated along with two known indole derived analogs from the deep-sea-sediment derived fungus Penicillium paneum SD-44 Compounds (Ib) and (II) exhibit potent cytotoxic activities against A-549 an HCT-116 cell lines.
01 Jan 2008
TL;DR: Singaporentine A (1) as discussed by the authors is a new indole alkaloid from the leaves of Kopsia singapurensis (Apocynaceae) which has shown cytotoxic activity against P388 murine leukemia cells.
Abstract: – Study on chemical constituents from the leaves of Kopsia singapurensis (Apocynaceae) yielded a new indole alkaloid, singaporentine A ( 1 ) together with two known alkaloids, kopsifoline A ( 2 ) and kopsininic acid ( 3 ). The structure of 1 was elucidated by combination of various spectroscopic methods such as MS, UV, IR, 1D and 2D NMR. Singaporentine A exhibited cytotoxic activity against P388 murine leukemia cells. INTRODUCTION The genus Kopsia (Apocynaceae) comprises of 30 species which is native to China, India and Southeast Asia. 1-7 This genus is known to produce a large number of biologically active indole alkaloids possessing interesting skeletons. 1-7 Various medicinal uses have been reported; the roots of K. larutensis King & Gamble, K. macrophylla Hook f., K. singapurensis Ridl. and K. pauciflora Hook f. are used to treat poulticing ulcerated noses in tertiary syphilis 8 while K. officinalis Tsiang & Li is used in Chinese traditional medicine for rheumatoid arthritis, dropsy and tonsillitis.
TL;DR: In this article, the vobasine-iboga type bisindole alkaloid, voacalgine F (I) was isolated and structure elucidation was performed.
Abstract: isolation and structure elucidation of the new vobasine-iboga type bisindole alkaloid, voacalgine F (I)
TL;DR: A new Erythrinan alkaloid (1), erythodine Noxide, was isolated from the seeds of Erystrina velutina together with seven known EryTHrinan alkaloids (2-7, 9) and an indole alkalinoid (8) by spectroscopic methods as mentioned in this paper.
Abstract: A new Erythrinan alkaloid (1), erythodine N-oxide, was isolated from the seeds of Erythrina velutina together with seven known Erythrinan alkaloids (2-7, 9) and an indole alkaloid (8). The structure of new compound (1) was elucidated by spectroscopic methods. Six of the nine compounds showed enhanced activity when combined with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Erysotrine (4) did not show cytotoxic activity by itself, but exhibited significant cytotoxicity when combined with TRAIL.
Patent•
31 May 2019
TL;DR: In this article, an anti-cancer compound, an indole alkaloid series compound, has been proposed, which can be used alone or in combination with other drugs and has a general formula (I).
Abstract: The invention relates to an anti-cancer compound, which is an indole alkaloid series compound and has a general formula (I). Indole alkaloids have a very good inhibitory effect on multiple solid tumors, such as human breast cancer cells, and further have an inhibitory effect on tumor growth. The compound has an inhibitory effect on the growth of cancer cells, but has no inhibitory effect on the growth of normal cells. The compound can be used alone or in combination with other drugs.