Topic
Indole alkaloid
About: Indole alkaloid is a research topic. Over the lifetime, 868 publications have been published within this topic receiving 15401 citations. The topic is also known as: indole alkaloids.
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TL;DR: The monoterpenoid indole alkaloids are a large family of structurally diverse compounds encompassing some of the most important plant medicinais discovered by man as discussed by the authors.
Abstract: The monoterpenoid indole alkaloids are a large family of structurally diverse compounds encompassing some of the most important plant medicinais discovered by man. Although these alkaloids were one of the last major groups of well-known natural products to have their biogenesis delineated, they have become one of the first classes of plant secondary metabolites to be studied at the enzymatic level. A contributory factor has been the excellent progress made by in vivo tracer work, which within a little more than a decade has led to the elucidation of the major features of a highly complicated pathway1,2.
44 citations
TL;DR: The first total synthesis of the C-2 symmetric indole alkaloid P-(+)-dispegatrine and four other monomeric sarpagine indoles alkaloids is described, with exclusive formation of a single atropodiastereomer 12.
Abstract: Non-phenolic oxidative coupling: The first total synthesis of the C-2 symmetric indole alkaloid P-(+)-dispegatrine (1) is reported. A late-stage thallium(III)acetate mediated intermolecular oxidative coupling was employed to construct the C(9)-C(9′) bond with complete regio- and stereocontrol. The exclusive formation of a single atropodiastereomer 12 in this critical step arises due to internal asymmetric induction, as planned. In addition, the first total synthesis of four other monomeric sarpagine indole alkaloids is described.
44 citations
TL;DR: In this paper, a monoterpenoid indole alkaloid possessing a unique peroxy bridge moiety was isolated from the whole plants of Catharanthus roseus and its structure was elucidated on the basis of NMR, IR, UV, and high-resolution mass spectrometric data, and its absolute configuration was determined by ECD and chemical methods.
44 citations
TL;DR: This review looks back on how the terpenoid indole alkaloid pathway and the regulatory factors in Catharanthus roseus were identified and characterized, and how metabolic engineering, including genetic engineering and metabolic profiling, was conducted based on the gained knowledge.
Abstract: This review looks back on how the terpenoid indole alkaloid pathway and the regulatory factors in Catharanthus roseus were identified and characterized, and how metabolic engineering, including genetic engineering and metabolic profiling, was conducted based on the gained knowledge. In addition, further examination of the terpenoid indole alkaloid pathway is proposed.
43 citations
TL;DR: From the dried roots of Neonauclea sessilifolia, two new chromone-secoiridoid glycosides, sessILifoside and 7"-O-beta-D-glucopyranosylsessilIFoside, and three novel indole alkaloid glyCosides, neonaucleosides A, B, and C, were isolated.
42 citations