Topic
Indole alkaloid
About: Indole alkaloid is a research topic. Over the lifetime, 868 publications have been published within this topic receiving 15401 citations. The topic is also known as: indole alkaloids.
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TL;DR: In this article, a short route to tetracyclic ring substructures of C-mavacurine, Strychnos, and akuammiline-type alkaloids, based on the addition of methyl 1-, 2-, or 3-indoleacetate anions to N-alkylpyridinium salts followed by acid cyclization of the resultant 1,4-dihydropyridines, is reported.
Abstract: A short route to tetracyclic ring substructures of C-mavacurine, Strychnos, and akuammiline-type alkaloids, based on the addition of methyl 1-, 2-, or 3-indoleacetate anions to N-alkylpyridinium salts followed by acid cyclization of the resultant 1,4-dihydropyridines, is reported. Further stereoselective elaboration of the C-20 (E)-ethylidene substituent results in the synthesis of the indole alkaloid vinoxine and of 4-ethylidene-hexahydro-1,5-methanoazocino [4,3-b]- and -[3,4-b] indoles
38 citations
TL;DR: Three monoterpenoid gluco-indole alkaloids, 3beta-isodihydrocad Ambine, cadambine, and 3alpha-dihyd Carbomethoxynaufoline were isolated from Nauclea cadamba ROXB, growing in Thailand.
Abstract: Three monoterpenoid gluco-indole alkaloids, 3beta-isodihydrocadambine, cadambine, and 3alpha-dihydrocadambine, were isolated from Nauclea cadamba ROXB. growing in Thailand. The stereochemistry at C19 in 3beta-isodihydrocadambine was elucidated to be R by spectroscopic analysis. Treatment of 3alpha-dihydrocadambine with beta-glucosidase in aqueous ammonium acetate solution gave an indolopyridine alkaloid, 16-carbomethoxynaufoline, and an unusually rearranged compound.
38 citations
TL;DR: Six oxindole alkaloids, not previously known as natural products, have been isolated from samples of U. attenuata and the variation in the alkaloid content of these three species is discussed.
38 citations
TL;DR: In this paper, three unusual natural products, viz., alstopirocine, a macroline alkaloid incorporating a substituted pyrrole moiety, pleiomaltinine, an alkaloidepyrone adduct, and pleiomalicine (pyrrole substituted with pleiocarpamine), were isolated from the Malayan Alstonia angustifolia.
38 citations
TL;DR: In this article, 209 glycosidic compounds have been identified from plants, microorganisms, and marine invertebrates that demonstrate different biological activities, such as antioxidants, anticancer, antimicrobial, and antibacterial agents.
Abstract: This review article presents 209 alkaloid glycosides isolated and identified from plants, microorganisms, and marine invertebrates that demonstrate different biological activities. They are of great interest, especially for the medicinal and/or pharmaceutical industries. These biologically active glycosides have good potential for future chemical preparation of compounds useful as antioxidants, anticancer, antimicrobial, and antibacterial agents. These glycosidic compounds have been subdivided into several groups, including: acridone; aporphine; benzoxazinoid; ergot; indole; enediyne alkaloidal antibiotics; glycosidic lupine alkaloids; piperidine, pyridine, pyrrolidine, and pyrrolizidine alkaloid glycosides; glycosidic quinoline and isoquinoline alkaloids; steroidal glycoalkaloids; and miscellaneous alkaloid glycosides.
38 citations