Topic
Indole alkaloid
About: Indole alkaloid is a research topic. Over the lifetime, 868 publications have been published within this topic receiving 15401 citations. The topic is also known as: indole alkaloids.
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TL;DR: The new sarpagine alkaloid, N(4)-methyltalpinine (1), was found to show significant NF-κB inhibitory activity (ED50 = 1.2 µM) and exhibited leishmaniacidal activity against promastigotes of Leishmania mexicana.
34 citations
TL;DR: In this article, three ring-fused monoterpenoid indole alkaloids, alstolactines A-C (1-3), were isolated from the long-term stored leaves of Alstonia scholaris.
34 citations
TL;DR: A new bis -indole alkaloid, spermacoceine, was isolated from the aerial parts of Borreria verticillata and its structure was established from spectroscopic data.
34 citations
TL;DR: A new indole alkaloid, naucline (1) together with four known alkaloids, angustine (2), angustidine (3), nauclefine (4), and naucletine (5) showed potent vasorelaxant activity on an isolated rat aorta.
Abstract: A new indole alkaloid, naucline (1) together with four known alkaloids, angustine (2), angustidine (3), nauclefine (4) and naucletine (5), were isolated from the bark of Nauclea officinalis. The structures of all isolated compounds were elucidated with various spectroscopic methods such as 1D- and 2D- NMR, IR, UV and LCMS-IT-TOF. In addition to that of alkaloid 1, the complete 13 C-NMR data of naucletine (5) were also reported. Naucline (1) showed a moderate vasorelaxant activity (90% relaxation at 1 × 10 −5 M) whereas, angustine (2), nauclefine (4), and naucletine (5) showed potent vasorelaxant activity (more than 90% relaxation at 1 × 10 −5 M) on an isolated rat aorta.
33 citations
TL;DR: The addition of 0.5 mg l−1 NAA to the culture medium remarkably enhanced the growth, and alkaloid production, of the hairy roots of Amsonia elliptica.
33 citations