scispace - formally typeset
Search or ask a question
Topic

Indole alkaloid

About: Indole alkaloid is a research topic. Over the lifetime, 868 publications have been published within this topic receiving 15401 citations. The topic is also known as: indole alkaloids.


Papers
More filters
Journal ArticleDOI
TL;DR: Ten new derivatives of dregamine and tabernaemontanine, two epimeric monoterpene indole alkaloids isolated from the methanol extract of the roots of TabernAemontana elegans, gave rise to ten new derivatives, showing promising apoptosis induction profile.

22 citations

Book ChapterDOI
01 Jan 1998
TL;DR: The use of secondary metabolites produced by organisms as systematic markers is as old as the use of morphological characters but has, until this century, been subjective as discussed by the authors, and has been subjective.
Abstract: The use of secondary metabolites produced by organisms as systematic markers is as old as the use of morphological characters but has, until this century, been subjective. For example, calling a plant aromatic was invariably an indication of the presence of volatile oils, whereas the sensation of “bitterness,” more often than not, denoted the presence of alkaloids.

22 citations

Journal ArticleDOI
TL;DR: A library of iridoid-conjugated indole alkaloid- like compounds was constructed from diversity-enhanced extracts, which constitutes an approach for increasing the chemical diversity of natural-product-like compounds by combining natural product chemistry and diversity-oriented synthesis.

22 citations

Journal ArticleDOI
TL;DR: Ethanol extract from Aspidosperma parvifolium trunk bark afforded uleine that is the major constituent of the alkaloid fraction and disclosed a good in vitroAnti-malarial activity against resistant and sensitive chloroquine Plasmodium falciparum strains.
Abstract: Several species of the genus Aspidosperma (Apocynaceae) are used for the treatment of human malaria in Brazil and other meso- and South American countries. Ethanol extract from Aspidosperma parvifolium trunk bark was submitted to acid–base extractions leading to alkaloid and neutral fractions. The alkaloid fraction was chromatographed over a silica gel column. Ethanol extract, fractions and uleine were analysed by HPLC–DAD, UPLC-ESI–MS/MS and HPLC-ESI-MicroTOF-MS. The anti-malarial activity was assayed against resistant and sensitive chloroquine Plasmodium falciparum strains by microscopic, [3H]-hypoxanthine incorporation and HRPII techniques. Cytotoxicity (CC50) was evaluated against Vero and HepG2 cell lines by the MTT technique; selectivity indexes (SI = CC50/IC50) were calculated. The major peak in the HPLC–DAD chromatograms of the ethanol extract, alkaloid and neutral fractions suggested the presence of uleine that was isolated from the alkaloid fraction by column chromatography and was characterized by spectroscopic methods. A total of 15 alkaloids, besides uleine, were identified in the alkaloid fraction by UPLC-DAD-ESI–MS/MS and HPLC-ESI-MicroTOF-MS. The ethanol extract from Aspidosperma parvifolium and the neutral fraction were moderately active against P. falciparum strains. The alkaloid fraction and uleine disclosed high anti-malarial activity against chloroquine-resistant P. falciparum strain (IC50 300 µg/mL). The alkaloid fraction showed moderate cytotoxicity to HepG2 cell line (CC50 = 74.4 µg/mL). High SI values (>10) were determined for all samples. Ethanol extract from Aspidosperma parvifolium trunk bark afforded uleine that is the major constituent of the alkaloid fraction and disclosed a good in vitro anti-malarial activity. Moreover, 15 other indole alkaloids have been identified along with uleine.

22 citations

Journal ArticleDOI
TL;DR: The indole alkaloid deplancheine (1) has been synthesised using a Witting reaction on the octahydro[2,3-a]quinolizin-2-one (2) itself available in four synthetic steps from readily available materials.

22 citations


Network Information
Related Topics (5)
Absolute configuration
7.8K papers, 124.7K citations
90% related
Triterpene
4.1K papers, 81.1K citations
89% related
Glycoside
4.6K papers, 80.8K citations
88% related
Indole test
19.9K papers, 318K citations
88% related
Isoquinoline
5.8K papers, 68.6K citations
88% related
Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202329
202254
202133
202029
201923
201828