Topic
Indole alkaloid
About: Indole alkaloid is a research topic. Over the lifetime, 868 publications have been published within this topic receiving 15401 citations. The topic is also known as: indole alkaloids.
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TL;DR: Two new indole alkaloid glycoside glycosides along with five known ones were obtained from the roots of I. tinctoria and showed inhibitory effects against LPS-stimulated RAW 264.7 cells.
19 citations
TL;DR: In an effort to study plants of the Rubiaceae from Panama, 299 herbarium samples, representing 133 species, were subjected to alkaloid screening, for the first time that 102 (94%) and 52 (90%) species are reported as alkaloids and indole alkaloidal bearing, respectively.
Abstract: In an effort to study plants of the Rubiaceae from Panama, 299 herbarium samples, representing 133 species, were subjected to alkaloid screening. From this total, 234 samples (78%) afforded a positive test for alkaloids, and 99 samples (33%) gave a positive reaction for indole alkaloids; 109 species (82%) contain alkaloids and 58 (44%) produce indole alkaloids. This is the first time that 102 (94%) and 52 (90%) species are reported as alkaloid and indole alkaloid bearing, respectively. The results of 10 out of 15 species, that is 67%, corroborate earlier studies. The richest indole alkaloid species were: Hamelia patens, Hamelia xerocarpa, Hoffmannia morii, Hoffmannia unguis-canceris, Deppea grandiflora, Elaeagia nitidifolia, Rondeletia secunda, Simira maxonii, Uncaria tomentosa, Gonzalagunia rosea, Isertia haenkeana, Isertia laevis, Posoqueria latifolia and Cinchona pubescens.
19 citations
TL;DR: The structures of the new humantenine-type and gelsemine-type oxindole alkaloids were determined by spectroscopic analyses as mentioned in this paper, and 6-hydroxyhumantenines (5) is the first example of a Gelsemium alkaloid with an oxygen function at C-6 position.
19 citations
TL;DR: In this paper, three pentacyclic indole alkaloids, one novel named darcyribeirine (1), and the known isoreserpiline (2) and isore serpine (3), were isolated from the root bark of the Rauvolfia grandiflora Mart.
19 citations
TL;DR: Three different strains of CATHARANTHUS ROSEUS cells were compared and no correlation was observed between the values of enzymatic activities and the contents of accumulated alkaloids.
Abstract: Three different strains of CATHARANTHUS ROSEUS cells were compared during one subculture with regard to tryptophan, tryptamine, ajmalicine, serpentine contents and tryptophane decarboxylase (TDC) (4) and Strictosidine synthase activities. The strains differed greatly in their accumulation of tryptamine and alkaloid. The TDC of all three strains showed the highest activity during the growth phase and declined sharply at the end of this phase. On the contrary, strictosidine synthase activity was the lowest during the growth phase and increased distinctly at the same time when the alkaloids were accumulating. By comparing the three strains with each other, no correlation was observed between the values of enzymatic activities and the contents of accumulated alkaloids.
18 citations