Topic
Indole alkaloid
About: Indole alkaloid is a research topic. Over the lifetime, 868 publications have been published within this topic receiving 15401 citations. The topic is also known as: indole alkaloids.
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TL;DR: In this paper, asperglaucins A and B (1 and 2) and neoechinulin F (8) were separated from the endolichenic fungus Aspergillus chevalieri SQ-8.
Abstract: Sixteen metabolites, including seven C7-alkylated salicylaldehyde derivatives (1-7) and nine prenylated indole alkaloids (8-16), three of which are new, namely, asperglaucins A and B (1 and 2) and neoechinulin F (8), were separated from the endolichenic fungus Aspergillus chevalieri SQ-8. Asperglaucin A (1) represents an unusual phthalide-like derivative with a benzo[c]thiophen-1(3H)-one scaffold. All compounds were assessed in vitro for antibacterial, antineuroinflammatory, and antioxidant activities. Notably, asperglaucins A and B exhibited potent antibacterial activities against two plant pathogens Pseudomonas syringae pv actinidae (Psa) and Bacillus cereus, with an MIC value of 6.25 μM; further SEM analyses illustrated that the possible bacteriostatic mechanisms for compounds 1 and 2 were to alter the external structure of B. cereus and Psa, and to cause the rupture or deformation of the cell membranes, respectively, and the results suggest that compounds 1 and 2 may serve as potential promising candidates for lead compounds of agrochemical bactericides. Furthermore, compounds 6 and 10 significantly inhibited nitric oxide production with an IC50 value of ca. 12 μM, and the possible anti-inflammatory mechanisms involved were also studied by molecular docking. Finally, the tested phenolics 3-5 showed significant antioxidative effects. Thus, strain SQ-8 represents a novel resource of these bioactive metabolites to be utilized.
18 citations
TL;DR: Alstoscholarisine K, an indole alkaloid with eight chiral carbons and featuring a novel 6/5/6/6,6, 6/6 and 6/ 6,6 octacyclic architecture, was found to be specific to the gall-infected leaves of Alstonia scholaris.
18 citations
TL;DR: From the rootbark of Tabernaemontana chippii, a novel antimicrobially active dimeric indole alkaloid was isolated which was assigned structure 1 on the basis of spectroscopic evidence and its synthesis as mentioned in this paper.
18 citations
TL;DR: The leaves of Mitragyna inermis (Willd.) O. Kuntze have been examined for alkaloids and shown to contain routundifoline, isorotund ifoline, rhynchophylline, isorbethine, ciliaphylline, Rhynchociline, speciophyllines, and traces of a second indole alkaloid which appears to be of the corynanthine type.
Abstract: The leaves of Mitragyna inermis (Willd.) O. Kuntze have been examined for alkaloids and shown to contain routundifoline, isorotundifoline, rhynchophylline, isorhynchophylline, ciliaphylline, rhynchociline, speciophylline, a small amount of uncarine F, mitraciliatine and traces of a second indole alkaloid which appears to be of the corynanthine type. There is also a polar compound present, Dragendorff positive, which remains on the base line when subjected to thin-layer chromatography with the usual solvent systems used for the mitragyna alkaloids.
18 citations
TL;DR: Isorosibiline is a new indole alkaloid derived form desacetylisoretuline, having C-16 configuration inverted to that of rosibilines.
Abstract: From Strychnos floribunda stem bark extracts, the alkaloids bisnordihydrotoxiferine, akagerine, decussine, rouhamine, Strychnocarpine, desacetylisoretuline and isorosibiline were isolated as well as a mixture of the sterols beta-sitosterol, stigmasterol and campesterol. Isorosibiline is a new indole alkaloid derived form desacetylisoretuline, having C-16 configuration inverted to that of rosibiline.
18 citations