Topic
Indole alkaloid
About: Indole alkaloid is a research topic. Over the lifetime, 868 publications have been published within this topic receiving 15401 citations. The topic is also known as: indole alkaloids.
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TL;DR: Two new oxindole alkaloids, rankiniridine (1 ) and humanteniridine(2 ), having a nitrogen-carbon linkage between a humantene-type monoterpenoid indole alkaloid and a monoterpene unit with an iridoid skeleton, were isolated from Gelsemium rankinii and Gelsemia elegans, respectively as mentioned in this paper.
18 citations
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18 citations
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TL;DR: This work describes a strategic approach for the synthesis of cyclohepta[b]indole structural scaffolds using a solvent-free Baylis-Hillman reaction of 2-bromobenzaldehydes and intramolecular Heck coupling reaction using Pd(OAc)2 as catalyst in the presence of benzyltrimethylammonium bromide under microwave condition.
Abstract: Ervatamine, silicine, methuenine, etc., are naturally occurring alkaloids that exhibit antimicrobial, anticancer, and anti-HIV activities. Indole fused with a seven-membered carbocyclic ring is a commonly observed structural feature among this series of bioactive compounds. This work describes a strategic approach for the synthesis of cyclohepta[b]indole structural scaffolds. The synthetic strategy consists of a solvent-free Baylis-Hillman reaction of 2-bromobenzaldehydes, followed by iodine-catalyzed C-alkylation of indole with the Baylis-Hillman adducts. Finally, intramolecular Heck coupling reaction using Pd(OAc)2 as catalyst in the presence of benzyltrimethylammonium bromide under microwave condition produced the desired cyclohepta[b]indole derivatives.
18 citations
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TL;DR: The ABC-rings of nodulisporic acid were found to contain the structural and stereochemical elements of the ABC-ring of the aldehyde as discussed by the authors, which is the most similar structure to ours.
18 citations
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TL;DR: Pamburus missionis root contained imperatorin and 7-hydroxy-8-(3′,7′-dimethyl octa-2′,6′-dien)ylcoumarin and a new natural product, 3-(3-methyl-1-oxo-2-butenyl) 1H indole.
17 citations