Topic
Indole alkaloid
About: Indole alkaloid is a research topic. Over the lifetime, 868 publications have been published within this topic receiving 15401 citations. The topic is also known as: indole alkaloids.
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TL;DR: Two new indole alkaloid derivatives (1, 2) together with six known indole alkaloids (3, 8) were isolated from the 70% EtOH/H2O extract of the stem of Naucleaofficinalis as discussed by the authors.
Abstract: Two new indole alkaloid derivatives (1, 2), together with six known indole alkaloids (3 – 8) were isolated from the 70% EtOH/H2O extract of the stem of Nauclea officinalis. Their structures were determined on the basis of extensive analyses of spectroscopic data (IR, MS, 1D- and 2D-NMR). All the isolates were evaluated for their anti-inflammatory activities on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7, and all the compounds showed significant inhibitory activities with the IC50 values of 0.82, 6.45, 9.75, 1.34, 3.40, 2.69, 1.58, and 1.96 μm, compared to the positive drug control group aminoguanidine with an IC50 value of 1.80 μm, especially compound 1 had the most significant activity.
17 citations
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TL;DR: Two cell lines of Tabernaemontana divaricata derived from the same suspension culture accumulate different amounts of the terpenoid indole alkaloids O-acetylvallesamine and voaphylline and the difference was shown to be due to the inability of the cell culture to biosynthesize both alkaloid.
Abstract: Two cell lines of Tabernaemontana divaricata derived from the same suspension culture accumulate different amounts of the terpenoid indole alkaloids O-acetylvallesamine and voaphylline. [15N]O-acetylvallesamine and [15N]voaphylline were added to the suspension cultures to investigate whether the lack of accumulating capacity of one of the cell lines was due to a low biosynthetic ability or to high turnover rates. The difference was shown to be due to the inability of the cell culture to biosynthesize both alkaloids. Both cell lines were able to metabolize O-acetylvallesamine. This metabolisation occurred mainly during the stationary phase. The alkaloids added were chemically unstable under culture conditions. Under normal batch cell culture conditions chemical breakdown is thought to play a minor role in the total amount of compound transformed.
17 citations
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TL;DR: The structure of guettardine 1, an indole alkaloid isolated from the bark of Guettarda heterosepala (Rubiaceae), was determined from an analysis of its MS, 1 H and 13 C NMR spectral data, and by a chemical correlation with dihydrocorynantheol 7 as discussed by the authors.
17 citations
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TL;DR: It is found that these new fosmidomycin analogues inhibited the accumulation of ajmalicine, a marker of monoterpenoid indole alkaloids production in plant cells.
17 citations
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TL;DR: A new indole alkaloid, murrayacarine together with 13 known compounds, 3-formylindole, omphalocarpin, 5,7-dimethoxy-8-(3′-methyl-2′-oxobutyl) coumarin, coumurrayin, murragleininin, mupanidin, mexoticin and murrangatin, and ferulyl esters were characterized on the basis of spectral analysis as discussed by the authors.
17 citations