Topic
Indole alkaloid
About: Indole alkaloid is a research topic. Over the lifetime, 868 publications have been published within this topic receiving 15401 citations. The topic is also known as: indole alkaloids.
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TL;DR: This work replaced the problematic phosphorylation step during synthesis with the mushroom kinase PsiK and consolidated the simplicity of tryptamine chemistry with the specificity and selectivity of enzymatic catalysis and helps provide access to an important drug at potentially reasonable cost.
Abstract: Psilocybin, the principal indole alkaloid of Psilocybe mushrooms, is currently undergoing clinical trials as a medication against treatment-resistant depression and major depressive disorder. The psilocybin supply for pharmaceutical purposes is met by synthetic chemistry. We replaced the problematic phosphorylation step during synthesis with the mushroom kinase PsiK. This enzyme was biochemically characterized and used to produce one gram of psilocybin from psilocin within 20 minutes. We also describe a pilot-scale protocol for recombinant PsiK that yielded 150 mg enzyme in active and soluble form. Our work consolidates the simplicity of tryptamine chemistry with the specificity and selectivity of enzymatic catalysis and helps provide access to an important drug at potentially reasonable cost.
16 citations
TL;DR: Two new monoterpenoid indole alkaloid derivatives and 11-methoxyjavaniside were found to effect relaxation of the supercoiled pBR322 plasmid DNA in the presence of Cu²+.
Abstract: Two new monoterpenoid indole alkaloid derivatives, turpiniside (1) and 11-methoxyjavaniside (2), along with the known alkaloids, vincosamide (3), (3 R)-pumiloside (4), and paratunamide C (5), were isolated from the leaves of Turpinia arguta (Lindl.) Seem. Their structures were determined on the basis of spectroscopic data. Compounds 1 and 3-5 were found to effect relaxation of the supercoiled pBR322 plasmid DNA in the presence of Cu²+.
16 citations
TL;DR: A new tetracyclic indole alkaloid, 17-O-methyl-3,4,5,6-tetradehydrogeissoschizine, together with seven known ones, were isolated from the aerial part of Uncaria rhynchophylla and showed potent to moderate antinematode activities against Panagrellus redivevus.
16 citations
TL;DR: The results demonstrate the high potential of the methodology for the synthesis of new pyrroloimidazoindole derivatives, which displayed moderate microM cytotoxicities in human cancer cell lines and at 10 microg/mL inhibited more than 50% EGFR or HIF-1alpha.
16 citations
TL;DR: Five pairs of new 2-oxoindole alkaloids, (±)-peganumalines A-E (1-5), and a new indoles alkaloid, peganumaline F (6), along with two known analogues, were isolated from the seeds of Peganum harmala through spectroscopic analyses and quantum chemistry calculations.
16 citations