Topic
Indole alkaloid
About: Indole alkaloid is a research topic. Over the lifetime, 868 publications have been published within this topic receiving 15401 citations. The topic is also known as: indole alkaloids.
Papers published on a yearly basis
Papers
More filters
TL;DR: Heteroyohimbine alkaloids, akuammigine and 3-isorauniticine, were synthesized using a modified Polonovski reaction followed by NaCNBH3 reduction from desmethylhirsuteine N-oxide as mentioned in this paper.
Abstract: Heteroyohimbine alkaloids, akuammigine and 3-isorauniticine, were synthesized using a modified Polonovski reaction followed by NaCNBH3 reduction from desmethylhirsuteine N-oxide, which was derived from the indole alkaloid hirsuteine Corynanthe alkaloid, corynantheidine was also synthesized using the same method from hirsuteine N-oxide
11 citations
Patent•
08 Aug 1995TL;DR: Indole alkaloid compounds having formula (I, where R and R' are H, an alkyl group having up to 5 carbon atoms or -CO-(CH2)n-CH3 where n = 0 to 16) are useful as both UV protective and anti-inflammatory agents as mentioned in this paper.
Abstract: Indole alkaloid compounds having formula (I), where R and R' are H, an alkyl group having up to 5 carbon atoms or -CO-(CH2)n-CH3 where n = 0 to 16. The indole alkaloid compounds and their reduction products are useful as both UV protective and anti-inflammatory agents.
11 citations
TL;DR: Indolactam I, a new congener of indole alkaloid tumor promoter teleocidins, was isolated from Streptoverticillium blastmyceticum, and was shown to be biosynthesized from N -methyl-L-isoleucyl-L -tryptophanol as discussed by the authors.
11 citations
TL;DR: In this review, recent results on the chemical synthesis of many skeletally varied Gelsemium alkaloids (Loganiaceae plant) are mainly described.
Abstract: Up to now, more than two thousands indole alkaloids having structural variety have been found from the three families of Gentianales: Loganiaceae, Apocynaceae, and Rubiaceae plants. These compounds generally possess characteristic biological activities and many of them are utilized for the medicinal purpose and for the lead-compounds to develop new synthetic drugs. The author of this review has been investigated the alkaloidal constituents of the above mentioned plants native to Japan and overseas countries. Especially, a cooperative work with Thai researchers concerning the plants in Thailand was developed. On the basis of biogenetic consideration of the structures of monoterpenoid indole alkaloids, chemical bond cleavage between the C3-N4 linkage in the C/D ring of indole alkaloids was discovered. It was speculated that, either in biogenesis, the flexibility of the ring-opening compounds having ten membered ring enabled the construction of indole alkaloids having highly strained polycyclic structures. Along with this conception, the syntheses of structurally complex indole alkaloids utilizing a biomimetic procedure have been investigated. In this review, recent results on the chemical synthesis of many skeletally varied Gelsemium alkaloids (Loganiaceae plant) are mainly described.
11 citations
TL;DR: The structures of a new sarpagine type indole alkaloid have been deduced from spectroscopic data; that of 5 has been confirmed by X-ray analysis.
Abstract: From CATHARANTHUS ROSEUS cell suspension cultures 16 R-19,20- E-isositsirikine ( 1), 16 R-19,20- Z-isositsirikine ( 2) and a new sarpagine type indole alkaloid ( 5) have been isolated. The structures have been deduced from spectroscopic data; that of 5 has been confirmed by X-ray analysis.
11 citations