Topic
Indole alkaloid
About: Indole alkaloid is a research topic. Over the lifetime, 868 publications have been published within this topic receiving 15401 citations. The topic is also known as: indole alkaloids.
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TL;DR: In this paper, a group of indole alkaloids, gelsepyrrodines A−C (1, 2), with a new gelsedine skeleton incorporated with a pyrrole ring, were isolated from the roots of Gelsemium elegans Benth.
11 citations
TL;DR: A new strychnine alkaloid was isolated from the leaves of Psychotria pilifera and exhibited potent antibacterial activity against Escherichia coli, equivalent to cefotaxime with MIC value of 0.781 μg/ml.
10 citations
TL;DR: The stems of Ervatamia yunnanensis have afforded a new indole alkaloid, ervataine, whose structure was determined by spectroscopic analysis.
10 citations
TL;DR: A short, stereospecfic total synthesis of indole alkaloid (±)-corynantheidine 1 was described in this paper, where the synthesis was carried out in a single step.
10 citations
TL;DR: The present data have shown that mitragynine is able to bind to opioid receptors, particularly MOR, to exhibit the analgesic effect and the updated pharmacological and toxicological properties of mitragyna speciosa and its diastereomers are discussed to render a comprehensive understanding of the pharmacological properties.
Abstract: Mitragynine, is a naturally occurring indole alkaloid that can be isolated from the leaves of a psychoactive medicinal plant. Mitragyna speciosa, also known as kratom, is found to possess promising analgesic effects on mediating the opioid receptors such as µ (MOR), δ (DOR), and κ (KOR). This alkaloid has therapeutic potential for pain management as it has limited adverse effect compared to a classical opioid, morphine. Mitragynine is frequently regarded to behave like an opioid but possesses milder withdrawal symptoms. The use of this alkaloid as the source of an analgesic candidate has been proven through comprehensive preclinical and clinical studies. The present data have shown that mitragynine is able to bind to opioid receptors, particularly MOR, to exhibit the analgesic effect. Moreover, the chemical and pharmacological aspects of mitragynine and its diastereomers, speciogynine, speciociliatine, and mitraciliatine, are discussed. It is interesting to know how the difference in stereochemical configuration could lead to the difference in the bioactivity of the respective compounds. Hence, in this review, the updated pharmacological and toxicological properties of mitragynine and its diastereomers are discussed to render a comprehensive understanding of the pharmacological properties of mitragynine and its diastereomers based on their structure–activity relationship study.
10 citations