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Ingenuity

About: Ingenuity is a research topic. Over the lifetime, 1112 publications have been published within this topic receiving 34024 citations.


Papers
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Journal ArticleDOI
27 Jul 2006-Nature
TL;DR: The manipulation of fluids in channels with dimensions of tens of micrometres — microfluidics — has emerged as a distinct new field that has the potential to influence subject areas from chemical synthesis and biological analysis to optics and information technology.
Abstract: The manipulation of fluids in channels with dimensions of tens of micrometres--microfluidics--has emerged as a distinct new field. Microfluidics has the potential to influence subject areas from chemical synthesis and biological analysis to optics and information technology. But the field is still at an early stage of development. Even as the basic science and technological demonstrations develop, other problems must be addressed: choosing and focusing on initial applications, and developing strategies to complete the cycle of development, including commercialization. The solutions to these problems will require imagination and ingenuity.

8,260 citations

Book
01 Jan 1999
TL;DR: Tomasello as discussed by the authors argued that the roots of the human capacity for symbol-based culture, and the kind of psychological development that takes p[lace within it, are based in a cluster of unique human cognitive capacities that emerge early in human ontogeny.
Abstract: This work builds a bridge between evolutionary theory and cultural psychology. The author is one of very few people to have done systematic research on the cognitive capacities of both nonhuman primates and human children. This work identifies what the differences are, and suggests where they might have come from. Tomasello argues that the roots of the human capacity for symbol-based culture, and the kind of psychological development that takes p[lace within it, are based in a cluster of unique human cognitive capacities that emerge early in human ontogeny. These include capacities fort sharing attention with other persons, for understanding that others have intentions of their own; and for imitating, not just what someone else does, but what someone else has intended to do. In this discussions of language, symbolic representation, and cognitive-development, the author describes with authority and ingenuity the "ratchet effect" of the capacities working over evolutionary and historical time to create the kind of cultural artifacts and settings within which each new generation of children develops. He also proposes a novel hypothesis, based on process of social cognition and cultural evolution, about what makes the cognitive representations of humans different from those of other primates.

3,901 citations

Journal ArticleDOI
TL;DR: This work presents a suite of algorithms and tools for inferring and scoring regulator networks upstream of gene-expression data based on a large-scale causal network derived from the Ingenuity Knowledge Base and extends the method to predict downstream effects on biological functions and diseases.
Abstract: Motivation: Prior biological knowledge greatly facilitates the meaningful interpretation of gene-expression data. Causal networks constructed from individual relationships curated from the literature are particularly suited for this task, since they create mechanistic hypotheses that explain the expression changes observed in datasets. Results: We present and discuss a suite of algorithms and tools for inferring and scoring regulator networks upstream of gene-expression data based on a large-scale causal network derived from the Ingenuity Knowledge Base. We extend the method to predict downstream effects on biological functions and diseases and demonstrate the validity of our approach by applying it to example datasets. Availability: The causal analytics tools ‘Upstream Regulator Analysis’, ‘Mechanistic Networks’, ‘Causal Network Analysis’ and ‘Downstream Effects Analysis’ are implemented and available within Ingenuity Pathway Analysis (IPA, http://www.ingenuity.com). Supplementary information: Supplementary material is available at Bioinformatics online.

3,828 citations

Journal ArticleDOI
TL;DR: Peter Drucker emphasizes that in seeking opportunities, innovators need to look for simple, focused solutions to real problems and cautions that if diligence, persistence, and commitment are lacking, companies are unlikely to succeed at the business of innovation.
Abstract: Some innovations spring from a flash of genius. But as Peter Drucker points out in this HBR Classic, most result from a conscious, purposeful search for opportunities. For managers seeking innovation, engaging in disciplined work is more important than having an entrepreneurial personality. Writing originally in the May-June 1985 issue, Drucker describes the major sources of opportunities for innovation. Within a company or industry, opportunities can be found in unexpected occurrences, incongruities of various kinds, process needs, or changes in an industry or market. Outside a company, opportunities arise from demographic changes, changes in perception, or new knowledge. These seven sources overlap, and the potential for innovation may well lie in more than one area at a time. Innovations based on new knowledge, of course, tend to have the greatest effect on the marketplace. But it often takes decades before the ideas are translated into actual products, processes, or services. The other sources of innovation are easier and simpler to handle, yet they still require managers to look beyond established practices. Drucker emphasizes that in seeking opportunities, innovators need to look for simple, focused solutions to real problems. The greatest praise an innovation can receive is for people to say, "This is obvious!" Grandiose ideas designed to revolutionize an industry rarely work. Innovation, like any other endeavor, takes talent, ingenuity, and knowledge. But Drucker cautions that if diligence, persistence, and commitment are lacking, companies are unlikely to succeed at the business of innovation.

1,591 citations

Book
01 Jan 2003
TL;DR: Teaching for the knowledge society - educating for ingenuity teaching beyond the KSS - from value for money to values for good teaching despite the knowledge societies I - the end of ingenuity teaching despite KSS II - the loss of integrity the KCS school - an endangered entity beyond standardization - professional learning communities or performance training sects? the future of teaching in the KSC - rethinking improvement, removing impoverishment.
Abstract: Teaching for the knowledge society - educating for ingenuity teaching beyond the knowledge society - from value for money to values for good teaching despite the knowledge society I - the end of ingenuity teaching despite the knowledge society II - the loss of integrity the knowledge society school - an endangered entity beyond standardization - professional learning communities or performance training sects? the future of teaching in the knowledge society - rethinking improvement, removing impoverishment.

1,198 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023195
2022317
202151
202038
201943
201845