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Innate immune system

About: Innate immune system is a(n) research topic. Over the lifetime, 45535 publication(s) have been published within this topic receiving 2750714 citation(s). The topic is also known as: innate immunity & non-specific immune system.

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Papers
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Open accessJournal ArticleDOI: 10.1038/NATURE01322
Lisa M. Coussens1, Zena Werb1Institutions (1)
19 Dec 2002-Nature
Abstract: Recent data have expanded the concept that inflammation is a critical component of tumour progression. Many cancers arise from sites of infection, chronic irritation and inflammation. It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration. In addition, tumour cells have co-opted some of the signalling molecules of the innate immune system, such as selectins, chemokines and their receptors for invasion, migration and metastasis. These insights are fostering new anti-inflammatory therapeutic approaches to cancer development.

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Topics: Cytokine (54%), Inflammation (52%), Innate immune system (52%)

11,085 Citations


Open accessJournal ArticleDOI: 10.1016/J.CELL.2006.02.015
24 Feb 2006-Cell
Abstract: Microorganisms that invade a vertebrate host are initially recognized by the innate immune system through germline-encoded pattern-recognition receptors (PRRs). Several classes of PRRs, including Toll-like receptors and cytoplasmic receptors, recognize distinct microbial components and directly activate immune cells. Exposure of immune cells to the ligands of these receptors activates intracellular signaling cascades that rapidly induce the expression of a variety of overlapping and unique genes involved in the inflammatory and immune responses. New insights into innate immunity are changing the way we think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.

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Topics: Pattern recognition receptor (67%), Innate immune system (65%), Acquired immune system (65%) ...read more

9,733 Citations


Open accessJournal ArticleDOI: 10.1038/NATURE05286
16 Nov 2006-Nature
Abstract: Many plant-associated microbes are pathogens that impair plant growth and reproduction. Plants respond to infection using a two-branched innate immune system. The first branch recognizes and responds to molecules common to many classes of microbes, including non-pathogens. The second responds to pathogen virulence factors, either directly or through their effects on host targets. These plant immune systems, and the pathogen molecules to which they respond, provide extraordinary insights into molecular recognition, cell biology and evolution across biological kingdoms. A detailed understanding of plant immune function will underpin crop improvement for food, fibre and biofuels production.

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8,968 Citations


Charles A. Janeway1, Ruslan Medzhitov1Institutions (1)
Abstract: ▪ Abstract The innate immune system is a universal and ancient form of host defense against infection. Innate immune recognition relies on a limited number of germline-encoded receptors. These receptors evolved to recognize conserved products of microbial metabolism produced by microbial pathogens, but not by the host. Recognition of these molecular structures allows the immune system to distinguish infectious nonself from noninfectious self. Toll-like receptors play a major role in pathogen recognition and initiation of inflammatory and immune responses. Stimulation of Toll-like receptors by microbial products leads to the activation of signaling pathways that result in the induction of antimicrobial genes and inflammatory cytokines. In addition, stimulation of Toll-like receptors triggers dendritic cell maturation and results in the induction of costimulatory molecules and increased antigen-presenting capacity. Thus, microbial recognition by Toll-like receptors helps to direct adaptive immune responses ...

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Topics: Immune receptor (71%), Pattern recognition receptor (70%), Innate immune system (66%) ...read more

7,595 Citations


Journal ArticleDOI: 10.1038/NRI1391
Shizuo Akira1, Kiyoshi Takeda2Institutions (2)
Abstract: One of the mechanisms by which the innate immune system senses the invasion of pathogenic microorganisms is through the Toll-like receptors (TLRs), which recognize specific molecular patterns that are present in microbial components. Stimulation of different TLRs induces distinct patterns of gene expression, which not only leads to the activation of innate immunity but also instructs the development of antigen-specific acquired immunity. Here, we review the rapid progress that has recently improved our understanding of the molecular mechanisms that mediate TLR signalling.

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Topics: Pattern recognition receptor (65%), TIRAP (64%), TLR8 (58%) ...read more

7,430 Citations


Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202246
20213,674
20203,407
20192,950
20182,733
20172,792

Top Attributes

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Topic's top 5 most impactful authors

Shizuo Akira

253 papers, 103.9K citations

Mihai G. Netea

204 papers, 21.4K citations

Victor Nizet

86 papers, 11.5K citations

Leo A. B. Joosten

79 papers, 9.7K citations

Alberto Mantovani

76 papers, 11.1K citations

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