scispace - formally typeset
Topic

Interferon

About: Interferon is a(n) research topic. Over the lifetime, 28969 publication(s) have been published within this topic receiving 1219645 citation(s). The topic is also known as: IFN & interferons.

...read more

Papers
  More

Journal ArticleDOI: 10.1146/ANNUREV.IMMUNOL.15.1.749
Abstract: Interferons are cytokines that play a complex and central role in the resistance of mammalian hosts to pathogens. Type I interferon (IFN-alpha and IFN-beta) is secreted by virus-infected cells. Immune, type II, or gamma-interferon (IFN-gamma) is secreted by thymus-derived (T) cells under certain conditions of activation and by natural killer (NK) cells. Although originally defined as an agent with direct antiviral activity, the properties of IFN-gamma include regulation of several aspects of the immune response, stimulation of bactericidal activity of phagocytes, stimulation of antigen presentation through class I and class II major histocompatibility complex (MHC) molecules, orchestration of leukocyte-endothelium interactions, effects on cell proliferation and apoptosis, as well as the stimulation and repression of a variety of genes whose functional significance remains obscure. The implementation of such a variety of effects by a single cytokine is achieved by complex patterns of cell-specific gene regulation: Several IFN-gamma-regulated genes are themselves components of transcription factors. The IFN-gamma response is itself regulated by interaction with responses to other cytokines including IFN-alpha/beta, TNF-alpha, and IL-4. Over 200 genes are now known to be regulated by IFN-gamma and they are listed in a World Wide Web document that accompanies this review. However, much of the cellular response to IFN-gamma can be described in terms of a set of integrated molecular programs underlying well-defined physiological systems, for example the induction of efficient antigen processing for MHC-mediated antigen presentation, which play clearly defined roles in pathogen resistance. A promising approach to the complexity of the IFN-gamma response is to extend the analysis of the less understood IFN-gamma-regulated genes in terms of molecular programs functional in pathogen resistance.

...read more

Topics: Antigen presentation (60%), Antigen processing (59%), Major histocompatibility complex (58%) ...read more

2,861 Citations


Journal ArticleDOI: 10.1126/SCIENCE.1087262
01 Aug 2003-Science
Abstract: Stimulation of Toll-like receptors (TLRs) triggers activation of a common MyD88-dependent signaling pathway as well as a MyD88-independent pathway that is unique to TLR3 and TLR4 signaling pathways leading to interferon (IFN)-beta production. Here we disrupted the gene encoding a Toll/IL-1 receptor (TIR) domain-containing adaptor, TRIF. TRIF-deficient mice were defective in both TLR3- and TLR4-mediated expression of IFN-beta and activation of IRF-3. Furthermore, inflammatory cytokine production in response to the TLR4 ligand, but not to other TLR ligands, was severely impaired in TRIF-deficient macrophages. Mice deficient in both MyD88 and TRIF showed complete loss of nuclear factor kappa B activation in response to TLR4 stimulation. These findings demonstrate that TRIF is essential for TLR3- and TLR4-mediated signaling pathways facilitating mammalian antiviral host defense.

...read more

Topics: TRIF (69%), Toll-like receptor (60%), TIRAP (58%) ...read more

2,809 Citations


Journal ArticleDOI: 10.1098/RSPB.1957.0048
Alick Isaacs1, Jean Lindenmann1Institutions (1)
Abstract: During a study of the interference produced by heat-inactivated influenza virus with the growth of live virus in fragments of chick chorio-allantoic membrane it was found that following incubation of heated virus with membrane a new factor was released. This factor, recognized by its ability to induce interference in fresh pieces of chorio-allantoic membrane, was called interferon. Following a lag phase interferon was first detected in the membranes after 3 h incubation and thereafter it was released into the surrounding fluid.

...read more

Topics: Viral Interference (57%), Virus (54%), Interferon (54%)

2,690 Citations


Journal ArticleDOI: 10.1126/SCIENCE.8009221
Ulrike Müller1, Ulrich Steinhoff1, Luiz F. L. Reis1, Silvio Hemmi1  +3 moreInstitutions (1)
24 Jun 1994-Science
Abstract: Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.

...read more

Topics: Janus kinase 1 (64%), Interferon (53%), Immune system (51%) ...read more

2,321 Citations


Open accessJournal ArticleDOI: 10.1126/SCIENCE.1232458
Lijun Sun1, Jiaxi Wu1, Fenghe Du1, Xiang Chen1  +1 moreInstitutions (1)
15 Feb 2013-Science
Abstract: The presence of DNA in the cytoplasm of mammalian cells is a danger signal that triggers host immune responses such as the production of type I interferons. Cytosolic DNA induces interferons through the production of cyclic guanosine monophosphate–adenosine monophosphate (cyclic GMP-AMP, or cGAMP), which binds to and activates the adaptor protein STING. Through biochemical fractionation and quantitative mass spectrometry, we identified a cGAMP synthase (cGAS), which belongs to the nucleotidyltransferase family. Overexpression of cGAS activated the transcription factor IRF3 and induced interferon-β in a STING-dependent manner. Knockdown of cGAS inhibited IRF3 activation and interferon-β induction by DNA transfection or DNA virus infection. cGAS bound to DNA in the cytoplasm and catalyzed cGAMP synthesis. These results indicate that cGAS is a cytosolic DNA sensor that induces interferons by producing the second messenger cGAMP.

...read more

2,304 Citations


Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20228
20211,146
20201,057
2019902
2018881
2017918

Top Attributes

Show by:

Topic's top 5 most impactful authors

Thomas C. Merigan

110 papers, 6.7K citations

Adolfo García-Sastre

107 papers, 14.4K citations

Jan Vilcek

86 papers, 5.8K citations

Michael Gale

75 papers, 11.7K citations

Ion Gresser

58 papers, 5.2K citations

Network Information
Related Topics (5)
Viral replication

33.4K papers, 1.6M citations

91% related
Virus

136.9K papers, 5.2M citations

91% related
Immune system

182.8K papers, 7.9M citations

90% related
Antibody

113.9K papers, 4.1M citations

90% related
CD8

44.4K papers, 2.2M citations

90% related