Topic
Interferon
About: Interferon is a research topic. Over the lifetime, 28969 publications have been published within this topic receiving 1219645 citations. The topic is also known as: IFN & interferons.
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TL;DR: Some aspects of the biology of IFN-γ, its pleiomorphic anti-cellular effects and its ability to modulate cellular responses to other regulatory factors are discussed.
676 citations
TL;DR: Results of Phase II/III hepatitis C clinical trials in humans confirmed the superior efficacy of pegylated interferon alpha-2a compared to unmodified interferons alpha- 2a.
673 citations
01 Jan 2013
TL;DR: Sofosbuvir plus ribavirin for 12 weeks may be effective in previously untreated patients with HCV genotype 1, 2, or 3 infection, and the rate of sustained virologic response 24 weeks after therapy is reported.
Abstract: BACKGROUND The standard treatment for hepatitis C virus (HCV) infection is interferon, which is administered subcutaneously and can have troublesome side effects. We evaluated so fos bu vir, an oral nucleotide inhibitor of HCV polymerase, in interferon-sparing and interferon-free regimens for the treatment of HCV infection. METHODS
671 citations
TL;DR: It is demonstrated that the induction of type I interferon by viruses deficient in 2′-O-methyltransferase was dependent on the cytoplasmic RNA sensor Mda5, which suggests that RNA modifications such as 2-methylation provide a molecular signature for the discrimination of self and non-self mRNA.
Abstract: The biological role of 2′-O-methylation of host and viral mRNA has remained elusive. Thiel and co-workers show that this modification modulates the induction of type I interferon and sensitivity to interferon.
669 citations
TL;DR: The current view on the balancing act between virus-induced IFN responses and the viral counterplayers is discussed.
667 citations