Topic
Intra-rater reliability
About: Intra-rater reliability is a research topic. Over the lifetime, 2073 publications have been published within this topic receiving 140968 citations.
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2 citations
TL;DR: In this article, the authors describe the intra-and inter-rater reliability of cough frequency measurements assessed by Vitalograph CAs from filtered 24-h cough recordings, and support the use of the VitaloJAK cough monitoring system to assess cough frequency in clinical trials.
Abstract: Background: Clinical trials of antitussive therapies increasingly use sound recording devices to assess cough frequency as an objective measure of efficacy. The VitaloJAK™ (Vitalograph, Buckingham, UK) comprises a digital sound recorder and a computer algorithm to filter out silence and most non-cough sounds from 24-h ambulatory recordings. Trained human cough analysts (CAs) listen to and inspect audio waveforms in the filtered recordings, tagging individual coughs which are tallied automatically. Recordings unsuitable for filtering are analyzed for the full 24 h. The reliability of Vitalograph CAs has not been previously documented. Objective: To describe the intra- and inter-rater reliability of cough frequency measurements assessed by Vitalograph CAs from filtered 24-h cough recordings. Methods: The recordings came from Phase 2 trials of gefipixant in patients with chronic cough. For intra-rater reliability, 13 CAs reviewed 1 randomly-selected recording two times, at least 1 month apart. For inter-rater reliability, 11 recordings were randomly selected and each was reviewed by 5 randomly-selected CAs. Intra-class correlations (ICC) to assess for absolute agreement were used to gauge reliability. Results: Across the 81 recording assessments, the median 24-h cough count was 356 (IQR: 167, 656). ICCs for both intra- and inter-rater reliability were found to be outstanding [0.999 (95% CI: 0.996, 1.000 and 0.999 (95% CI:0.997, 1.000), respectively]. Conclusions: The cough frequencies assessed by Vitalograph CAs were highly reliable. These results support the use of the VitaloJAK cough monitoring system to assess cough frequency in clinical trials.
2 citations
01 Jan 2017
TL;DR: This chapter discussesSoftware reliability and dependability, and covers topics such as software reliability and software reliability models, the Cleanroom methodology, system availability, safety and security critical software, and dependable software engineering.
Abstract: This chapter discusses software reliability and dependability, and covers topics such as software reliability and software reliability models, the Cleanroom methodology, system availability, safety and security critical software, and dependability engineering
2 citations
23 Aug 2013
2 citations