Topic
Intramolecular reaction
About: Intramolecular reaction is a research topic. Over the lifetime, 5015 publications have been published within this topic receiving 138213 citations.
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TL;DR: In this paper, the authors proposed a method to construct an octane-1-carboxylic acid (CSA) from a carboxyl acid (CARB) with a 4-acetoxybicycle.
Abstract: l-bromobicyclo[2.2.2]octane, 7697-09-8; 4-acetoxybicyclo[2.2.2]octane-1-carboxylic acid, 72963-86-1; 4-chlorobicyclo[2.2.2]octane-1-carbonyl fluoride, 94994-06-6; 4-(trifluromethyl) bicyclo[2.2.2Joctan-l-o1, 94994-07-7; l-(tert-butyl)-4-methoxybicyclo[2.2.2]octane, 81687-94-7; l-iodo-4-methylbicyclo[2.2.2Joctane, 55044-63-8; 1-methoxy-4-methylbicyclo[2.2.2]octane, 6555-95-9; 4-phenylbicyclo[2.2.2Joctane-l-amine, 10206-89-0; 4-phenylbicyclo[2.2.2]octane-l-carboxylic acid, 953-69-5; 4-phenylbicyclo[2.2.2Joctane-l-carboxamine, 23744-33-4; l-cyano-4phenylbicyclo[2.2.2Joctane, 950-22-1; 4-[1-(trimethylsily1)ethynyl]bicyclo[2.2.2Joctane-l-carboxaldehyde, 94994-08-8; 4iodobicyclo[2.2.2Joctane-l-carboxaldehyde, 94994-09-9; 1,l-dichloro-2-(4-iodobicyclo[2.2.2Joct-1-yl)ethene, 94994-10-2; l-(trimethylsilyl)-2-(4-iodobicyclo[2.2.2]oct-l-yl)ethyne, 94994-11-3; 4-fluorobicyclo[2.2.2]octane-l-carboxylic acid, 78385-84-9; bicyclo[2.2.2]octane-l-methanol, 2574-42-7; 4-nitrobicyclo[2.2.2Joctane-1-methanol, 94994-12-4; 4-cyanobicyclo[2.2.2]octane-lmethanol, 94994-13-5; 4-(trifluoromethyl)bicyclo[2.2.2]octane-lmethanol, 94994-14-6; methyl 4-(hydroxymethyl)bicyclo[ 2.2.21octane-1-carboxylate, 94994-15-7; 4-fluorobicyclo[2.2.2]octane-lmethanol, 94994-16-8; 4-chlorobicyclo[2.2.2]octane-l-methanol, 94994-17-9; 4-bromobicyclo[2.2.2]octane-l-methanol, 94994-18-0; 4-methoxybicyclo[2.2.2]octane-l-methanol, 94994-19-1; 4phenylbicyclo[2.2.2]octane-l-methanol, 23760-80-7; 4-methylbicyclo[2.2.2Joctane-l-methanol, 28305-83-1; 4-tert-butylbicyclo[2.2.2]octane-l-methanol, 94994-20-4; 4-iodobicyclo[ 2.2.2loctane1-methanol, 94994-21-5; bicyclo [ 2.2.21 octane1carboxaldehyde, 2064-05-3; 4-nitrobicyclo[2.2.2Joctane-lcarboxaldehyde, 94994-22-6; 4-cyanobicyclo[2.2.2]octane-lcarboxaldehyde, 94994-23-7; 4-(trifluromethyl) bicyclo[2.2.2]0~tane-1-carboxaldehyde, 94994-24-8; 4-carbomethoxybicyclo[2.2.2Joctane-l-carboxaldehyde, 94994-25-9; 4-fluorobicyclo[2.2.2]octane-l-carboxaldehyde, 78385-82-7; 4-chlorobicyclo[2.2.2]octane-l-carboxaldehyde, 94994-26-0; 4-bromobicyclo[ 2.2.2]octane-l-carboxaldehyde, 94994-27-1; 4-methoxybicyclo[2.2.2]octane-l-carboxaldehyde, 94994-28-2; 4-phenylbicyclo[2.2.2]octane-l-carboxaldehyde, 94994-29-3; 4-methylbicyclo[2.2.2]octane-l-carboxaldehyde, 94994-30-6; 4-tert-butylbicyclo[2.2.2]octane-l-carboxaldehyde, 94994-31-7; 4-ethynylbicyclc[2.2.2]octane-l-carboxaldehyde, 94994-32-8; 4-ethynylbicyclo[2.2.2]octane-l-methanol, 94994-33-9; 4-ethynylbicyclo[2.2.2]0~tane-1-carboxylic acid, 94994-34-0; bicyclo[2.2.2]octane-lcarboxylic acid, 699-55-8; 4-bromobicyclo[ 2.2.2]octane-l-carboxylic acid, 1989-50-0; 4-chlorobicyclo[2.2.2]octane-l-carboxylic acid, 1007-73-4; 4-methylbicyclo[2.2,2]octane-l-carboxylic a id, 702-67-0; 4-nitrobicyclo[ 2.2.2]octane-l-carboxylic acid, 775-65-5; 4-cyanobicyclo[2.2.2]octane-l-carboxylic acid, 15941-09-0; l-methoxybicyclo[2.2.2]octane, 7697-14-5; 4-methoxybicyclo[ 2.2.2 Joctane1-carboxylic acid, 773-34-2; methanol, 67-56-1; iodine monochloride, 7790-99-0; chlorine, 7782-50-5; iodine, 7553-56-2; iodotrimethylsilane, 16029-98-4; l-nitro-4-phenylbicyclo[2.2.2]octane, 64852-68-2; methyl 4-phenylbicyclo[2.2,2]octane-l-carboxylate, 23062-52-4; chlorotrimethylsilane, 75-77-4; N-formylpiperidine, 2591-86-8; carbon monoxide, 630-08-0.
60 citations
TL;DR: In this paper, a quantitative model based upon Allinger's MM2 force field was devised to calculate the diastereoselectivity of intramolecular Diels-Alder (IDA) reactions.
Abstract: A quantitative model based upon Allinger's MM2 force field has been devised to calculate the diastereoselectivity of intramolecular Diels-Alder (IDA) reactions. The parameters for the modified MM2 force field were derived whenever possible from ab initio calculations on the intermolecular transition structure for the Diels-Alder reactions of butadiene plus ethylene, acrolein, and acrolein coordinated to BH 3 . The force field reproduces the ab initio 3-21G transition structures for the intramolecular Diels-Alder reactions of 1,3,8-nonatriene and 1,3,9-decatriene
60 citations
TL;DR: A series of unsaturated α-diazo carbonyl compounds underwent enantioselective intramolecular cyclopropanation (ee = 4-77%) when treated with an enantiomerically pure chiral copper catalyst as discussed by the authors.
60 citations
TL;DR: The title radical precursors were prepared from secondary amides by reaction of the amide with phosgene to give an imidoyl chloride followed by reaction with the sodium salt of N-hydroxypyridine-2-thione to give 3,4-benzoindolizidinone products.
Abstract: The title radical precursors were prepared from secondary amides by reaction of the amide with phosgene to give an imidoyl chloride followed by reaction with the sodium salt of N-hydroxypyridine-2-thione. Visible light initiated reactions of these precursors gave amidyl radicals 2 which could react with their precursors to give N-(2-pyridylthio) amides or with t-BuSh to give the parent amide. Radicals 2 containing δ,e-unsaturation on the acyl or alkyl chain cyclized in a 5-exo fashion to give ultimately γ-lactams and N-acylpyrrolidines, respectively. Tandem 5-exo cyclizations of the N-allyl-4-pentenamidyl radical gave pyrrolizidinone products, and a tandem 5-exo/6-endo reaction sequence of the N-(4-pentenyl)benzamidyl radical gave, ultimately, 3,4-benzoindolizidinone
60 citations
TL;DR: In this article, C-H activation of benzylic methyl groups has been realized catalytically under mild conditions through intramolecular reaction on a palladium complex with mild conditions.
60 citations