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Intramolecular reaction

About: Intramolecular reaction is a research topic. Over the lifetime, 5015 publications have been published within this topic receiving 138213 citations.


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Journal ArticleDOI
TL;DR: In this paper, it was shown that oxidation of a monocyclic radical to a cation precedes cyclization to form 3, 4, 7, and 8, respectively.

54 citations

Journal ArticleDOI
TL;DR: Boron trifluoride etherate promotes both in situ formation of N-tosyliminium complexes from olefinic enolizable aldehydes and subsequent intramolecular electrophilic cyclization to afford homoallylic amines.

54 citations

Journal ArticleDOI
TL;DR: The reaction mechanisms of the PtCl 4- and Au(I)-catalyzed intramolecular acetylenic Schmidt reactions were analyzed by means of hybrid density functional calculations at the B3LYP/6-31G*(LANL2DZ) level of theory for better understanding of the acceleration effect of ethanol solvent in PtCl4- catalyzed reaction and the different catalytic activities of Au and Pt catalysts.
Abstract: The reaction mechanisms of the PtCl4- and Au(I)-catalyzed intramolecular acetylenic Schmidt reactions were analyzed by means of hybrid density functional calculations at the B3LYP/6-31G*(LANL2DZ) level of theory for better understanding of the acceleration effect of ethanol solvent in PtCl4-catalyzed reaction and the different catalytic activities of Au and Pt catalysts. Calculations indicate the rate of the PtCl4-catalyzed reaction in noncoordinative solvent of 1,2-dichloroethane is limited by isomerization of the relatively stable chelate complex to the reactive π-complex of PtCl4 with the acetylenic moiety of homopropargyl azide substrate, which requires an activation energy of 29.6 kcal/mol. All nucleophilic cyclization, dinitrogen elimination, and 1,2-H shift of metal-carbene steps are quite facile. The generation of 2H-pyrrole intermediate in PtCl4-catalyzed reaction is completed by a ligand substitution reaction, and the final 2H-pyrrole to 1H-pyrrole isomerization is an intermolecular process with...

54 citations

Journal ArticleDOI
TL;DR: The synthesis of (-)-hamigeran B has been achieved, based on a new approach to cyclopentane construction, the rhodium-mediated intramolecular C-H insertion of alpha-aryl-alpha-diazoketones through selective hydrogenation of a cyclopropylidene substituent.
Abstract: The synthesis of (−)-hamigeran B has been achieved, based on a new approach to cyclopentane construction, the rhodium-mediated intramolecular C−H insertion of α-aryl−α-diazoketones. The endo-isopropyl group was installed by selective hydrogenation of a cyclopropylidene substituent.

54 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20231
20228
20216
202011
20199
20186