Topic
Intramolecular reaction
About: Intramolecular reaction is a research topic. Over the lifetime, 5015 publications have been published within this topic receiving 138213 citations.
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TL;DR: Cyclisation radicalaire de bromo-2 hexenes-1 substitues et fonctionnalises, en methylcyclopentanes correspondants as mentioned in this paper, en methyl-cyclopentane correspondants
Abstract: Cyclisation radicalaire de bromo-2 hexenes-1 substitues et fonctionnalises, en methylcyclopentanes correspondants
162 citations
TL;DR: In this article, a sequential catalytic process based on gold-catalyzed nucleophilic addition of terminal alkynes to imines, and gold-car catalyzed intramolecular reaction of aromatic ring to alkynes was developed.
162 citations
TL;DR: Operationally simple Au(I)-catalyzed intramolecular hydroarylation reactions of terminal alkynes that proceed in high yield and under very mild conditions are described.
Abstract: Operationally simple Au(I)-catalyzed intramolecular hydroarylation (IMHA) reactions of terminal alkynes that proceed in high yield and under very mild conditions are described. These processes involve low catalyst loadings, mild reaction temperatures, and short reaction times, require no cocatalysts or additives, and allow for the generation of a number of important heterocyclic motifs from readily accessible starting materials.
162 citations
TL;DR: A straightforward, efficient, and more sustainable copper-catalyzed method has been developed for intramolecular N-arylation providing the benzimidazole ring system, exclusively carried out in water, rendering the methodology highly valuable from both environmental and economical points of view.
Abstract: A straightforward, efficient, and more sustainable copper-catalyzed method has been developed for intramolecular N-arylation providing the benzimidazole ring system. With Cu2O (5 mol %) as the catalyst, DMEDA (10 mol %) as the ligand, and K2CO3 as the base, this protocol was applied to synthesize a small library of benzimidazoles in high yields. Remarkably, the reaction was exclusively carried out in water, rendering the methodology highly valuable from both environmental and economical points of view.
161 citations
TL;DR: The reaction of the internal alkyne with alcohols 2 in the presence of a catalytic amount of Pd(PPh3)4 and benzoic acid in dioxane at 100°C gave the allylic ethers 3 in good to high yields as discussed by the authors.
161 citations