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Intramolecular reaction
About: Intramolecular reaction is a research topic. Over the lifetime, 5015 publications have been published within this topic receiving 138213 citations.
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TL;DR: In this article, the Silver ion catalysed intramolecular cyclisation of R′C6H4CCCOC6H3(OH)R at room temperature gives the corresponding aurone (2a-d) as the major product with a trace amount of the flavone; compounds (1a,d) could be prepared by the addition of the corresponding lithium acetylide (4a,b) to the substituted salicyl aldehyde (5a,c), followed by MnO2 oxidation.
Abstract: Silver(I) ion catalysed intramolecular cyclisation of R′C6H4CCCOC6H3(OH)R (1a–d) at room temperature gives the corresponding aurone (2a–d) as the major product with a trace amount of the flavone; compounds (1a–d) could be prepared by the addition of the corresponding lithium acetylide (4a–b) to the substituted salicyl aldehyde (5a–c), followed by MnO2 oxidation.
41 citations
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TL;DR: The homoallylic diazoacetates 3a-j underwent enantioselective intramolecular cyclopropanation with the rhodium catalyst Rh 2 (5 S -MEPY) 4 ( 1 ) to give the oxabicyclo[4.1.0]heptanes 4a−j in 71-90% enantiomeric excess and in 55-80% chemical yield.
41 citations
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TL;DR: The synthesis of a variety of alkylidene benzoxacycles via a domino palladium-catalyzed ortho-alkylation/intramolecular Heck reaction is described, and aryl iodides with oxygen-tethered Heck acceptors are coupled withAlkyl bromides to generate a range of six- and seven-membered-ring benzoxACYclic products.
Abstract: The synthesis of a variety of alkylidene benzoxacycles via a domino palladium-catalyzed ortho-alkylation/intramolecular Heck reaction is described. Under the optimized conditions [Pd(OAc)2 (10 mol %), P(2-Furyl)3 (20 mol %), norbornene (4 equiv), Cs2CO3 (2 equiv), CH3CN, 80 °C], aryl iodides with oxygen-tethered Heck acceptors are coupled with alkyl bromides (5 equiv) to generate a variety of six- and seven-membered-ring benzoxacyclic products.
41 citations
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TL;DR: Synthese de tri-, tetra-and pentamethylene-1,6 1H-pyridones-2 a partir de methoxy-2 pyridine et d'ω-[perhydropyrannyl-2oxy] propyl-, -butyl- and -pentyllithiums as discussed by the authors.
Abstract: Synthese de tri-, tetra- et pentamethylene-1,6 1H-pyridones-2 a partir de methoxy-2 pyridine et d'ω-[perhydropyrannyl-2oxy] propyl-, -butyl- et -pentyllithiums
41 citations
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TL;DR: In this paper, a Pd-catalyzed intramolecular acetylene hydroarylation protocol was used for the synthesis of the azocino[b]indole framework.
41 citations