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Intramolecular reaction
About: Intramolecular reaction is a research topic. Over the lifetime, 5015 publications have been published within this topic receiving 138213 citations.
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TL;DR: A successful Palladium catalysed intramolecular coupling of phenyl rings corresponding to amino acids (R)-4-hydroxyphenylglycine (5 ) and (S)-3,5-dihydroxymhenyl glycine(7 ) of vancomycin is achieved.
40 citations
TL;DR: The intramolecular conjugate addition of an amine to the chiral vinyl sulfoxides 3 and 4 to give chiral isoquinolines 5 and 6 was reported in this article.
40 citations
40 citations
TL;DR: In this paper, the cyclization of 1-[2-(chloromethyl)-4,5-(methylenedioxy)phenyl]-3-(2-azidoethyl)cyclohex-1-ene at 140 o C caused the following sequence of events: (1) intramolecular 1,3-dipolar cycloaddition of the azide onto the alkene; (2) formation of a imine by loss of nitrogen from the triazoline intermediate with concomitant hydrogen migration; and (3) N-alkylation of
Abstract: Cyclization of 1-[2-(chloromethyl)-4,5-(methylenedioxy)phenyl]-3-(2-azidoethyl)cyclohex-1-ene at 140 o C caused the following sequence of events: (1) intramolecular 1,3-dipolar cycloaddition of the azide onto the alkene; (2) formation of a imine by loss of nitrogen from the triazoline intermediate with concomitant hydrogen migration; and (3) intramolecular N-alkylation of the imine nitrogen with the benzylic chloride
40 citations
TL;DR: In this paper, an efficient direct synthesis of oxazolidinones fused to six-membered heterocyclic rings starting from carbamate-protected aminoalkenes has been developed.
Abstract: An efficient, direct synthesis of oxazolidinones fused to six-membered heterocyclic rings starting from carbamate-protected aminoalkenes has been developed. This procedure is based on an oxidative palladium(II)-catalyzed reaction performed in the presence of stoichiometric copper chloride, which is determinant to promote the formation of the bicyclic product and prevent the isolation of the monocyclic amination product. Oxazolidinone compounds arise from a domino aminocarboxylation process through the direct intervention of the carbamate oxygen after the initial palladium-promoted transfer of the nitrogen atom on the C=C double bond.
40 citations