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Intramolecular reaction
About: Intramolecular reaction is a research topic. Over the lifetime, 5015 publications have been published within this topic receiving 138213 citations.
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81 citations
TL;DR: Pd-catalyzed intramolecular selenocarbamoylation of alkynes leading to alpha-alkylidene-beta-lactams was developed as discussed by the authors.
Abstract: Pd-catalyzed intramolecular selenocarbamoylation of alkynes leading to alpha-alkylidene-beta-lactams was developed. This reaction can be applied to thiocarbamoylation and to the synthesis of delta- and epsilon-lactams and a cyclobutanone.
81 citations
TL;DR: It is noteworthy that two azaquaternary tricyclic products were synthesized through a two-step pathway involving an electrophilic ipso-cyclization and then an intramolecular Heck reaction.
Abstract: A novel electrophilic ipso-cyclization involving an electrophile-exchange process has been developed. In the presence of CuX (X = I, Br, SCN) and electrophilic fluoride reagents, a variety of N-(p-methoxyaryl)propiolamides and 4-methoxyphenyl 3-phenylpropiolate were cyclized to selectively afford the corresponding spiro[4.5]decenones in moderate to good yields. It is noteworthy that two azaquaternary tricyclic products were synthesized through a two-step pathway involving an electrophilic ipso-cyclization and then an intramolecular Heck reaction.
80 citations
TL;DR: In this article, a route to macrocyclic polystyrene of controlled dimensions based on a new ring closure process has been investigated, which involved the direct coupling of an α-acetal, φ-bis(hydroxymethyl) heterodifunctional linear poly styrene precursor previously prepared by living anionic polymerization.
Abstract: A route to macrocyclic polystyrene of controlled dimensions based on a new ring closure process has been investigated. It involved the direct coupling of an α-acetal,ω-bis(hydroxymethyl) heterodifunctional linear polystyrene precursor previously prepared by living anionic polymerization. Cyclization was achieved under high dilution, by intramolecular condensation of the polymer ends in the presence of a mild acid as catalyst. Macrocyclic polystyrenes were prepared directly in high yield (>90%) without any necessary fractionation step. The synthesis and structural characterization of both the linear α,ω-heterodifunctional precursors and the corresponding cyclized polystyrenes, as well as a preliminary investigation of their stability and specific thermal properties, are reported.
80 citations
80 citations