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Intramolecular reaction
About: Intramolecular reaction is a research topic. Over the lifetime, 5015 publications have been published within this topic receiving 138213 citations.
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72 citations
TL;DR: Copper carbenoids undergo efficient intramolecular insertion into allyl ethers, and the resulting ylide-type species rearrange to furnish cyclic ethers (ring sizes 6-8) in high yield.
71 citations
TL;DR: Palladium-catalyzed intramolecular cross-coupling reactions between aryl iodides and allyl moieties were successfully demonstrated in the presence of palladium catalyst, tri-o-tolylphosphine, a tertiary amine, and water.
Abstract: Palladium-catalyzed intramolecular cross-coupling reactions between aryl iodides and allyl moieties were successfully demonstrated in the presence of palladium catalyst, tri-o-tolylphosphine, a tertiary amine, and water. Several kinds of trans-2,4-disubstituted 1,2,3,4-tetrahydroquinolines were synthesized in 73−88% yields with excellent diastereoselectivities. This method was further applied to a large variety of substrates to form five-, six-, and seven-membered carbo- and heterocycles in good yields, regardless of the ring-containing atom, via microwave-assisted conditions.
71 citations
TL;DR: In this article, a cyclization of the acryloyl 2′-bromoanilide 1a with a "ligandless" palladium(0) catalyst was shown to yield the pentacyclic oxindole 2a (ds = 9:1).
71 citations
TL;DR: High enantioselective [4 + 2] cycloaddition can be achieved by cationic Rh complexes bearing not only chiral phosphine but also chiral diene, the first example of asymmetric synergy between chiral dienes and diphosphines.
Abstract: High enantioselective [4 + 2] cycloaddition can be achieved by cationic Rh complexes bearing not only chiral phosphine but also chiral diene. This is the first example of asymmetric synergy between chiral dienes and diphosphines.
71 citations