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Intramolecular reaction

About: Intramolecular reaction is a research topic. Over the lifetime, 5015 publications have been published within this topic receiving 138213 citations.


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Journal ArticleDOI
TL;DR: This unprecedented tandem reaction between N-substituted alpha-bromoacetamides and Michael acceptors proceeds with good yields and excellent diastereoselectivity to provide the corresponding trisubstituting gamma-lactam systems.
Abstract: A new and highly diastereoselective tandem reaction aza-Michael/intramolecular nucleophilic substitution is presented. This unprecedented tandem reaction between N-substituted α-bromoacetamides and Michael acceptors proceeds with good yields and excellent diastereoselectivity to provide the corresponding trisubstituted γ-lactam systems. An application to the concise synthesis of the tricyclic core of (±)-martinelline alkaloids is also described.

65 citations

Journal ArticleDOI
TL;DR: Generation of an intramolecularly tethered, nonracemic diaryl cuprate followed by its oxidation with ground state oxygen at −78° leads to a biaryl precursor to an ellagitannin this paper.

65 citations

Journal ArticleDOI
TL;DR: Synthese de spiroacetals des systemes dioxa-1,7spiro [5.5] undecane et Dioxa]-1,6spiro as mentioned in this paper [4] decane a partir d'α-hydroxyalkyl-5 furannebutanols-2 et -furannepropanols -2 via la cyclisation acide des alkyl-2 dihydro-3,6 hydroxy-6 w-hydroxyl- et -propyl-2 pyrannones
Abstract: Synthese de spiroacetals des systemes dioxa-1,7spiro [5.5] undecane et dioxa-1,6spiro [4.5] decane a partir d'α-hydroxyalkyl-5 furannebutanols-2 et -furannepropanols-2 via la cyclisation acide des alkyl-2 dihydro-3,6 hydroxy-6 w-hydroxybutyl- et -propyl-2 pyrannones-3

65 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20231
20228
20216
202011
20199
20186